L-PRF in Alveolar Ridge Preservation

Tomographic and Histological Evaluation of Postextraction Sockets Treated With Leucocyte- and Platelet-rich Fibrin: a Randomized Clinical Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03408418

Acronym

L-PRF

Enrollment

Registered

2018-01-24

Start date

2018-03-01

Completion date

2019-03-01

Last updated

2019-03-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bone Loss, Alveolar

Keywords

Platelet-rich fibrin, Tooth Extraction, Alveolar Bone Grafting

Brief summary

The effect of leucocyte- and platelet-rich fibrin (L-PRF) for enhancing the healing after dental extractions is still a matter of debate. The available literature suggests that L-PRF performs positive effect to improve alveolar preservation resulting in less bone resorption on extraction sockets. L-PRF is a second generation of platelet concentrate produced without biochemical blood manipulation. L-PRF is composed by three key parameters: first, the presence of platelets; second, the presence of leucocytes; third, the density and complex organization of the fibrin matrix architecture produced by a natural polymerization process. The theory is that this key parameters acts to produce a faster bone healing.

Interventions

PROCEDUREPlatelet-rich fibrin

The use of autologous platelet-rich fibrin after tooth extraction to promote bone healing and alveolar ridge preservation

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

17 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* (1) Health patients, American Society of Anesthesiologists (ASA) I or II * (2) Patients who need to submit tooth extraction (pre-molar, canine and incisor teeth - uniradicular teeth or teeth with fused roots) which present ideal conditions to receive dental implants after 3 months.

Exclusion criteria

* Smoking * Systemic diseases related with healing disorders * Poor oral hygiene * Pregnant or lactating patient * Use of flap elevation for dental extraction

Design outcomes

Primary

Measure	Time frame	Description
Width resorption 1mm	After 3 months	The ridge width differences between baseline and after three months of healing 1 mm below the crest.

Secondary

Measure	Time frame	Description
Width resorption 5mm	After 3 months	The ridge width differences between baseline and after three months of healing 5 mm below the crest.
Histological Analysis - fibrous tissue	After 3 months	The percentage of soft (fibrous) tissue
Width resorption 3mm	After 3 months	The ridge width differences between baseline and after three months of healing 3 mm below the crest.
Histological Analysis - capillary vessels	After 3 months	Quantity of capillary vessels
Histological Analysis - new bone formation	After 3 months	The percentage of the newly formed bone
Histological Analysis - bone cells	After 3 months	Quantity of bone cells (osteoblast, osteoclast and osteocyte)

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 1, 2026