Impact of Platelet Activation in Intracranial Aneurysm Rupture Risk - PLAQRAN

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03408379

Acronym

PLAQRAN

Enrollment

230

Registered

2018-01-24

Start date

2017-12-20

Completion date

2033-06-23

Last updated

2026-01-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intracranial Aneurysms, Ruptured Aneurysm

Keywords

intracranial aneurysms, ruptured aneurysm, platelet activity

Brief summary

Sub arachnoid hemorrhage consecutive to intracranial aneurysm rupture is a devastating disease. Predictors of intracranial aneurysm rupture are limited and focus mainly on size and location. Platelet activation may have a deleterious role on aneurysm rupture. The assumption is that patients with ruptured intracranial aneurysm will present a higher rate of platelet activation compared to patients with non ruptured aneurysms.

Interventions

OTHERCollection of blood sample in aneurysm

In case of an endovascular treatment : * A blood sample (venous or arterial) of 10 ml will be taken at the beginning of the procedure, an intra aneurysmal blood sample (1mL) will be taken during the procedure and a blood sample (arterial) of 1 mL will be taken at the end of the procedure. * Iterative blood samples (arterial) of 10 mL will be taken at each follow up visit. In case of a surgery treatment : * A blood sample (venous or arterial) of 10 ml will be taken at the beginning of the surgery. * A Tissue sample will be taken during the surgery * Iterative blood samples (arterial) of 10 mL will be taken at each follow up visit.

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patient aged 18 and over * Patient presenting a single or multiple aneurysm * Patient presenting an intracranial aneurysm for which an intervention is planned (endovascular treatment or surgery) : elective intervention for an unruptured aneurysm or emergency surgery for a broken aneurysm

Exclusion criteria

* Pregnant or breast feeding woman * Patient benefiting from legal protection measures

Design outcomes

Primary

Measure	Time frame	Description
Proportion of patients with platelet activation	in the 7 days before embolisation	comparison of this proportion between patients with ruptured versus non ruptured intracranial aneurysm

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026