Traumatic Brain Injury
Conditions
Brief summary
The purpose of this study is to examine the effects of exercise on recovery after traumatic brain injury. Investigators will determine if exercise enhances rehabilitation by increasing substances (proteins) that can facilitate recovery.
Detailed description
Exercise-based therapies can promote recovery of function and are easily implemented in the clinical rehabilitation setting. This study will determine if exercise facilitates recovery by improving markers of neuroplasticity and decreasing neuroinflammatory responses. The investigators will also determine if variations in genes involved in neuroplasticity, memory and inflammation influence the responsiveness to exercise and rehabilitation. Particular genetic polymorphisms involved in neuroplasticity and inflammatory responses will be evaluated. Recovery will be determined by assessing cognitive function, life quality and balance.
Interventions
Aerobic exercise will be performed with a treadmill or stationary tandem bike 3 times per week. Each exercise session will take about 30 minutes plus 5 to 10 min of warm-up and cool-down. Participants will wear a safety harness.
OTHERRehabilitation
Rehabilitative program is focused on completion of activities of daily living, initiation, appropriate behavior and community integration for five days per week at the Centre for Neuro Skills.
Sponsors
Centre for Neuro Skills
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Intervention will consist of aerobic exercise sessions at predetermined heart rate range.
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Clinical diagnosis of TBI (for R+AER and R groups). * Fluency in English or Spanish. * Able to walk with or without a device.
Exclusion criteria
* Orthopedic or cardiac conditions that prevent from exercising. * Current diagnosis of neurological and/or psychiatric diseases. Unable to be in the Los Angeles CA metropolitan area for the duration of the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Aerobic Exercise Induced Changes in Cognitive Function | 5 years | Attention, processing speed, reaction times, memory and nonverbal reasoning are evaluated by CNS Vital Signs. All scores are aggregated to one reported value (Neurocognitive Index). Scoring is by a computer based auto-scored multivariate scoring system developed by the manufacturers. |
| Aerobic Exercise Induced Changes in Inflammatory responses to exercise | 4 to 30 weeks depending on the duration of rehabilitation coverage. | Selected analytes will be evaluated from serum. |
| Aerobic Exercise Induced Changes in Cardio Pulmonary Fitness | 4 to 30 weeks depending on the duration of rehabilitation coverage. | Ventilatory Threshold (aerobic capacity) |
| Aerobic Exercise Induced Changes in Neuroplasticity responses to exercise | 4 to 30 weeks depending on the duration of rehabilitation coverage. | Selected analytes will be evaluated from serum. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Aerobic Exercise Induced Changes in Depression Symptoms | 4 to 30 weeks depending on the duration of rehabilitation coverage. | Beck Depression Inventory |
| Genetic polymorphisms involved in Inflammatory and neuroplasticity responses to aerobic exercise. | 4 to 30 weeks depending on the duration of rehabilitation coverage. | Genetic material will be obtained. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Verbal Memory | 4 to 30 weeks depending on the duration of rehabilitation coverage. | California Verbal Learning Test (CVLT II). |
| Quality of Life | 4 to 30 weeks depending on the duration of rehabilitation coverage. | Quality of Life in Neurological Disorders (Neuro-QoL) |
| Visual Search/Processing Speed | 4 to 30 weeks depending on the duration of rehabilitation coverage. | Trail Making |
Countries
United States
Contacts
Primary ContactGrace S Griesbach, PhD
Backup ContactLisa Kreber, PhD
Outcome results
None listed