Stroke
Conditions
Keywords
upper limb, recovery, somatosensory, impairment, electroencephalography, acute phase
Brief summary
This clinical study is organized for people with stroke often experience difficulties with their sensation in their upper limb. New technologies may be able to help these important problems. However, there is currently not enough knowledge about how the brain recovers in people with sensory impairments in their arm and hand. Using a non-invasive technique of recording brain activity, known as electroencephalography (EEG), brain activity in combination with somatosensation of the hand will be measured. Therefore, the purpose of this study will be to analyse brain activity in relation to somatosensory impairments after stroke during the first two weeks after stroke.
Interventions
DIAGNOSTIC_TESTElectroencephalography
EEG is a device to measure brain activity via surface electrodes
Sponsors
Universitaire Ziekenhuizen KU Leuven
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
Participants will be recruited during the first 2-3 days post-stroke. They should have: 1. a first-ever unilateral, supra-tentorial stroke, as defined by Wold Health Organisation; 2. admission to the acute hospital, 3. deficit in distal pinprick somatosensory measured by Rivermead assessment of somatosensory performance (score of ≤4) and/or motor impairment measured by Fugl Meyer Assessment (score of ≤12 out of 14), 4. the age of \> 18 years and 5. the ability to provide informed consent. Healthy adults will also be recruited and they should have: 1. no history of sensory impairments in their hands 2. the age of \> 18 years and 3. the ability to provide informed consent.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Sensory Evoked Potential Latency | First 2 weeks post-stroke | EEG measurement |
| Sensory Evoked Potential Amplitude | First 2 weeks post-stroke | EEG measurement |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Perceptual Threshold of Touch | First 2 weeks post-stroke | Light touch of the palmar surface of index finger |
| Erasmus modified Nottingham Sensory Assessment | First 2 weeks post-stroke | Measures somatosensation of the upper limb and hand |
| Fugl Meyer Assessment | First 2 weeks post-stroke | Upper limb motor impairment measurement |
| Montreal Cognitive Assessment | First 2 weeks post-stroke | Measures cognition |
| Nottingham Sensory Assessment | First 2 weeks post-stroke | Measures stereognosis |
| Wolf Motor Function Test | First 2 weeks post-stroke | Upper limb activities measurement |
Countries
Belgium
Outcome results
None listed