Chronic Obstructive Pulmonary Disease, Midazolam Overdose, Respiratory Failure, Weaning Failure
Conditions
Brief summary
Daily interruption of sedation is one of the modalities which is known to enhance early weaning and separation from mechanical ventilation . Daily sedation interruption is also known to help decreasing incidence of ventilator associated pneumonia. The new modality is no sedation.
Detailed description
there is an increase of incidence of chronic obstructive lung disease associated respiratory failure which necessitates invasive mechanical ventilation. It is well known that one of the bundles for enhanced recovery of such cases is the daily interruption of sedation . Recently studies have demonstrated the feasibility of just using sedation for initiation of mechanical ventilation, then utilization of no sedation technique as a more this offers less side effects .
Interventions
DRUGDaily interruption of midazolam
daily at 7 am midazolam infusion will be stopped spontaneous breath trial will be done
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Obstructive lung disease * Respiratory failure * Invasive mechanical ventilation
Exclusion criteria
* Neurological deficit * Cognitive dysfunction * Extensive malignancy * septic Shock
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| duration of mechanical ventilation | first 30 days | number of days of mechanical ventilation |
Countries
Egypt
Outcome results
None listed