Obstructive Jaundice
Conditions
Keywords
Methylene blue; Peripheral vascular resistance
Brief summary
To explore the effects of pre-treatment with methylene blue on reduced perioperative vascular resistance in patients with obstructive jaundice.
Detailed description
Hemodynamic characteristics of patients with obstructive jaundice are high cardiac output, low peripheral vascular resistance. The molecular basis for this feature is the increased production of NO. Methylene blue can increase peripheral resistance, the mechanism is: methylene blue is an oxidoreductase inhibitor, can inhibit the increased production of NO in the vascular endothelium, thereby increasing peripheral vascular resistance.
Interventions
DRUGMethylene Blue
2mg / Kg of methylene blue in volume of 50ml is administrated I.V before anesthesia induction.
Sponsors
Southwest Hospital, China
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
1. Aged between 18-60 years; 2. American Society of Anesthesiologists（ASA） grade I\ III; 3. TBIL\>ULN and TBA\>ULN; The patients with obstructive jaundice.
Exclusion criteria
1. Organs dysfunction(heart,lungs and etc); 2. Mental disorders; 3. in other clinical trial.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Peripheral vascular resistance | through operation completion, an average of 6 hours | the dose of vasoconstrictors used to Maintain Peripheral vascular resistance in the normal range (800 \ 1200dyns / cm5) |
Countries
China
Contacts
Primary ContactNing Jiaolin, Doctor
Outcome results
None listed