Normal Fertile, Repeated Implantation Failure
Conditions
Brief summary
Characterization of the uterine microbiome in women with repeated implantation failure as well as in normal fertile women.
Detailed description
In the midluteal phase of the cycle, a vaginal swab and endometrial biopsy will be obtained.
Interventions
OTHERVaginal swab + endometrial biopsy
In the midluteal phase of the cycle, a vaginal swab (E swab) and endometrial biopsy (TAO brush) will be obtained.
Sponsors
University Ghent
University Hospital, Ghent
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 39 Years
Healthy volunteers
Yes
Inclusion criteria
* Women between their 18th and 40th birthdays (max 39 years and 364 days at the day of signing the informed consent) * Able to understand, read and speak Dutch and hence to provide written and oral informed consent * Negative serological tests for human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), Rapid plasma reagin (RPR) for syphilis
Exclusion criteria
* Hormonal contraception in current cycle * Presence of intra-uterine device * Antibiotic treatment in the current cycle
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Midluteal uterine microbiome profile | 1 week | Descriptive analysis of the uterine microbiome present |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Midluteal vaginal microbiome profile | 1 week | Descriptive analysis of the vaginal microbiome present (quality control of endometrial sampling) |
Countries
Belgium
Outcome results
None listed