Sickle Cell Disease, Sickle Cell Trait
Conditions
Keywords
Sickle cell, Heterozygous, Blood donor
Brief summary
Bearers of the sickle cell allele (S) are currently eligible for blood donations in Belgium. As blood donors are not tested for this allele, their heterozygous status is unknown. However, guidelines recommend to transfuse sickle cell patients with blood that is negative for the 'S' hemoglobin. To the investigator's knowledge, no study has been conducted to evaluate the impact of transfusion with blood originating from heterozygous donors on the transfusion performance and the improvement of clinical status of the sickle cell disease patients.
Interventions
PROCEDUREBlood sampling
Extra blood samples taken for laboratory analysis
Sponsors
Hanane EL KENZ
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
All patients with sickle cell disease within the CHU Brugmann and the Queen Fabiola Children's Hospital (HUDERF)
Exclusion criteria
None
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Hemoglobin level -patient | 1 hour before blood transfusion | Hemoglobin level (g/dL) |
| % of 'S' type hemoglobin -patient | 1 hour before blood transfusion | % of 'S' type hemoglobin (assessed by means of hemoglobin electrophorese) |
| Hemoglobin level - transfused blood | 1 hour before blood transfusion | Hemoglobin level (g/dL) |
| % of 'S' type hemoglobin -transfused blood | 1 hour before blood transfusion | % of 'S' type hemoglobin (assessed by means of hemoglobin electrophorese) |
| Transfusion yield | 1 hour after blood transfusion | Computed by means of a formula taking the level of hemoglobin, the % of 'S' type hemoglobin and the body surface into account. |
| Medical complications | 1 month | List of medical complications having occured after a surgery. Applicable only to the 'transfusion prior to surgery' groups. |
| Length of stay | 1 month | Length of stay within the hospital. Applicable only to the 'acute transfusion' groups |
| Length of stay post transfusion | 1 month | Length of stay within the hospital after a blood transfusion. Applicable only to the 'acute transfusion' groups |
| Number of blood transfusions | 1 month | Number of blood transfusions. Applicable only to the 'acute transfusion' groups |
| Hospital re-admission | 1 month | Hospital re-admission. Applicable only to the 'acute transfusion' groups |
| Mortality rate | 1 month. | Mortality rate. Applicable only to the 'acute transfusion' groups |
Countries
Belgium
Outcome results
None listed