Diabetes Mellitus, Kidney, CPB
Conditions
Brief summary
Filtration of urine in the kidney requires sufficient oxygen supply. The filtration of urine is greater in patents with diabetes. Our theory is that the diabetic kidney has a higher oxygen demand than the non diabetic kidney thereby making the diabetic kidney more sensitive to decreased oxygen delivery following reduced blood flow. With a catheter inserted into the kidney vein we will monitor the blood flow and oxygen saturation before and during CPB, in patient with diabetes.
Interventions
DIAGNOSTIC_TESTDM-ECC
Diabetes mellitus CPB
Sponsors
Sahlgrenska University Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Patients with diabetes mellitus * Serum creatinine \< 150 micromol/L preoperative * Heart surgery requiring CPB * LV (left ventricle) EF \>40 % * Normal hemoglobin
Exclusion criteria
\-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Renal O2 extraction | 2 years | Renal O2 extraction measured by sampling blood from a catheter inserted into the kidney vein. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| GFR | 2 years | GFR (Glomerular filtration rate), measured with CrEDTA- and PAH- clearance. |
| Renal blood flow | 2 years | Change in renal blood flow measured by sampling blood from a catheter inserted into the kidney vein |
Countries
Sweden
Outcome results
None listed