Healthy Volunteers, Skeletal Muscle, Sleep Deprivation
Conditions
Brief summary
The investigator showed that a night of sleep deprivation halved the duration of an inspiratory endurance test and that this loss of endurance could be secondary to a lack of activation of the pre-motor cortex. However, the inspiratory endurance test is associated with a feeling of dyspnea that could lead to premature arrest, and the inspiratory drive is complex, both automatic and voluntary. The investigator can reproduce this results on a simpler drive. During the execution of an exercise involving repeated contractions of the hand it is possible to record the activation of the pre-motor cortex corresponding to the phase of preparation of the movement. The amplitude of these premotor potentials is proportional to the developed motive force. The purpose of this study is to assess the impact of sleep deprivation on the muscular endurance of non-dominant in healthy subjects. Hypothesis: Sleep deprivation causes a decrease in manual motor endurance by decreasing cortical pre-motor control. Main objective: To compare the motor endurance of healthy subjects after a night's sleep and after a sleepless night. Secondary objective: To compare the amplitude of premature cortical control at the beginning of the endurance test after a night's sleep and after a sleepless night.
Interventions
BEHAVIORALNormal sleep night
Usual hours of sleep
BEHAVIORALSleepless night
Total sleep deprivation the first night
Sponsors
Poitiers University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Outcomes Assessor)
Masking description
When analyzing the results (endurance, magnitude of the premotor potential), the outcomes assessor will not know if it is a normal night or a sleepless night
Intervention model description
To compare the motor endurance of healthy subjects after a normal sleep night and after a sleepless night.
Eligibility
Sex/Gender
MALE
Age
25 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* adult male volunteers; * 25 to 45 years old * regularly sleeping more than 6 hours per night; * no excessive consumers of coffee (\<3 espressos / day); * absence of muscular or neurological pathology ; * with a BMI\> 18 and \<25 kg / m²; * Horne and Ostberg score\> 31 and \<69 ;
Exclusion criteria
* female sex * history of neuromuscular disease ; * implanted metallic or electronic equipment (vascular stent, ocular implant, pacemaker ...) * history of epilepsy, or discomfort after sleep deprivation ; * poor sleepers (PSQI\> 5); * exercising an activity in staggered hours; * regularly performing more than 2 nights without sleep per month; * taking drugs interfering with sleep (antidepressants, benzodiazepines ...); * having crossed 4 time zones in the previous 4 weeks. * current participation in another clinical research study;
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Test duration | 1 hour. | Time, in minutes, measured between the beginning of the endurance test and the end of the test, defined by the volunteer's inability to maintain a force of at least 30% of the maximum strength for 5 seconds. |
Countries
France
Outcome results
None listed