Acute Effects of Propylene Glycol/Glycerol Intake on Blood Parameters

Acute Effects of Propylene Glycol/Glycerol Intake on Cardiorespiratory Blood Parameters

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03404011

Acronym

AEPGGIBP

Enrollment

Registered

2018-01-19

Start date

2018-01-15

Completion date

2018-12-30

Last updated

2019-04-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Metabolic Complication

Brief summary

The aim of this study is to evaluate the acute effect of propylene glycol and glycerol intake on cardiorespiratory blood parameters.

Detailed description

Background : Propylene glycol/glycerol intake is increasingly popular. Acute effect of propylene glycol and glycerol intake on cardiorespiratory blood parameters is unknown. The investigators postulate that intake of propylene glycol and glycerol could modifiy cardiorespiratory blood parameters. Aims of this study : to test the following hypotheses : 1\) Acute intake of propylene glycol and glycerol modifies cardiorespiratory blood parameters. To test this hypothesis, we will perform blood samples before and after intake of propylene glycol and glycerol. Participants will be tobacco smoker between 18 and 70 years old, with multiple cardiovascular risk factors, and who will undergo a cardiac catherization. After the cardiac catherization, the catheter will be used to perform serial blood samples.

Interventions

OTHERPropylene glycol and Glycerol intake

Intake of 1 gram of propylene glycol/Glycerol mix (50:50). Blood sample before, 5 minutes and 20 minutes after intake.

DEVICEMimicking intake

Mimicking propylene glycol/glycerol intake with the device turns off. Blood sample before, 5 minutes and 20 minutes after intake.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

* Subject undergoing cardiac catherization * Subject must be an active tobacco smoker

Exclusion criteria

* Symptoms of infection or inflammation * Acute disease including heart rhythm disorder, acute coronary syndrome or decompensation of a chronic disease (heart failure, COPD,...) * Unexpected and undesirable effects during the cardiac catherization procedure * Respiratory failure requiring supplementary oxygen

Design outcomes

Primary

Measure	Time frame	Description
Cardiorespiratory biological variables	5 minutes	Blood sample

Secondary

Measure	Time frame	Description
Cardiorespiratory biological variables	20 minutes	Blood sample

Countries

Belgium

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026