Right Ventricular Dysfunction
Conditions
Brief summary
Mono-center Study to evaluate different multimodal functional parameter of the right ventricle in PAH-patients
Detailed description
Mono-center-study tu evaluate functional parameters in cardiac MRI, conductance catheter (pressure-volume-loops), echocardiography and right heart catheter in PAH patients and to compare different multimodal parameters
Interventions
DIAGNOSTIC_TESTconductance catheter
pressure volume loops are assessed via a special catheter (Conductance catheter)
Sponsors
German Research Foundation
University of Giessen
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* PH Nizza group 1 and patients without pulmonary hypertension after having the right heart catheter on clinical grounds * ability to sign informed consent * male and female between 18 to 85 years * haemodynamic criteria: * Pulmonary vascular resistance (PVR) \> 240 dyn x sec x cm-5 * Mean Pulmonary artery pressure (mPAP) ≥ 25 mmHg for PAH patients * normal haemodynamic in controls * therapy-naive or at least since two months stabil therapy with approved drugs for PAH (Sildenafil, Tadalafil, Macitentan, Ambrisentan, Bosentan, Iloprost, Treprostinil, Riociguat).
Exclusion criteria
* therapy with positive inotropic drugs (dobutamin etc.) * missing informed consent * pregnancy or lactation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Comparibility of Ees (endsystolic elastance, which describes the right ventricular contractility) derived from conductance catheter, cMRI (cardiac magnetic resonance tomography) and 4D echocardiography | 12 weeks | right ventricular contractility can be obtained via different methods, our aim is to compare the different methods. Ees is the endsystolic elastance which describes the contractility of the right ventricle |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| dp/dt max and min from Pressure-Wire vs. Conductance Katheter | 12 weeks | delta pressure/delta time is an indirect parameter of right ventricular contractility, which is load dependent |
| Comparibility of volumetry assessed via magnetic resonance tomography (MRI) and 4D echocardiography (ECHO) | 12 weeks | Volumes (end-diastolic and endystolic) are measured via MRI and ECHO and compared with each other |
| Comparibility of pressures measured via pressure wire and conductance catheter | 12 weeks | pressurewire measurements (high fidelity catheter) and conductance catheter (pressure volume catheter) are compared with each other |
Countries
Germany
Contacts
Primary ContactKhodr Tello, MD
Backup ContactManuel Richter, MD
Outcome results
None listed