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Brain Attack Surveillance in Corpus Christi--Cognitive (BASIC-Cognitive)

Brain Attack Surveillance in Corpus Christi--Cognitive (BASIC-Cognitive)

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT03403257
Acronym
BASIC-C
Enrollment
634
Registered
2018-01-18
Start date
2018-04-11
Completion date
2026-04-30
Last updated
2026-05-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dementia, Dementia Alzheimers, Dementia, Mixed, Dementia, Vascular

Keywords

Caregiving, Hispanic, Mexican American, Epidemiology, Community

Brief summary

The Mexican American population in the U.S. is rapidly growing and aging. This project seeks to determine the prevalence and outcomes of cognitive impairment and dementia in Mexican Americans. It also seeks solutions to help patients with cognitive impairment and dementia and their caregivers get the resources they need.

Detailed description

Hispanic/Latinos will comprise more than 30% of the U.S. population by mid-century, and Mexican Americans account for the largest share of this growing segment of society. This proposal aims to use door-to-door surveillance in Nueces County, Texas, a non-immigrant, bi-ethnic community, to determine the prevalence and trajectory over time of cognitive impairment and dementia in Mexican Americans and non Hispanic whites. The study will elucidate the mechanisms that explain the hypothesized ethnic disparity in Alzheimer's disease and Alzheimer-related dementias by evaluating the roles of vascular disease risk factors, educational attainment and socio-economic status among others. This research will also delve deeply into the differences in informal caregiving for Mexican American and non Hispanic whites with cognitive impairment and dementia. Caregiver burden and mental and physical health of caregivers will be examined toward efforts to develop interventions that build resilience in caregivers. A novel ability of this population-based study is to examine community resources for both patients and caregivers, and how these provisions differ by ethnicity. Using a rigorous mixed methods approach the study will identify the gap between available resources and needs for those with cognitive impairment and dementia. In this way we will be well positioned to propose ethnic-specific testable interventions that promote mental and physical health for those with cognitive impairment and dementia, as well as for those family members who provide the care. This research will therefore lead to improved well-being, autonomy and outcomes among those with cognitive impairment and dementia and their caregivers. The investigative team members have conducted research in this community for 20 years and are experts in Mexican American culture and health, cognitive impairment and dementia, epidemiologic methods, community needs assessment and health behavior research. As the Mexican American population continues its tremendous growth and aging it is vitally important to better understand the prevalence and outcomes of cognitive impairment and dementia in this population, and to rapidly develop interventions that address the burden of these common conditions in Mexican American adults, families, and communities.

Interventions

OTHERNo interventions

No intervention

Sponsors

University of Michigan
Lead SponsorOTHER
National Institutes of Health (NIH)
CollaboratorNIH

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No

Inclusion criteria

1.65 years of age or older 2. MoCA \< 26 3. Nueces County resident at least 6 months a year 4. English or Spanish speaking 5. Community dwelling or nursing home

Exclusion criteria

none

Design outcomes

Primary

MeasureTime frameDescription
Prevalence of mild cognitive impairment and dementia in Mexican Americans and non Hispanic whites2 year data collectionPrevalence estimates
Trajectory of cognitive function in Mexican Americans and non Hispanic whites2 year follow-up after baselineChange in cognitive function among subjects entered at baseline
Caregiver outcomes and changes over time4 yearsComparative caregiver outcomes among Mexican Americans and non Hispanic whites

Secondary

MeasureTime frameDescription
Needs and community available resources for cognitive impairment2 yearsAn asset map and determination of needs

Countries

United States

Contacts

PRINCIPAL_INVESTIGATORLewis Morgenstern, MD

University of Michigan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: May 23, 2026