Breast Cancer
Conditions
Brief summary
The resistivity measurements will be done by introducing a needle-probe into fresh healthy, peritumoral, and tumoral ex vivo tissues.
Detailed description
Patients affected by breast cancer will have their tissue analysed immediately following their surgical excision for the treatment of breast cancer. Two probes will be used: a linear probe of 4 needle-electrodes positioned in a row that is able to perform Electrical Impedance Spectroscopy (EIS) measurements and a circular probe of 8 needle-electrodes arranged into a circular pattern that is able to generate cross sectional images (Electrical Impedance Tomography maps). Firstly, the linear probe will be inserted in the tumor parenchyma at a penetration depth of about 2 mm and the tissue impedance measurement will be performed along a broad spectrum of frequencies for few minutes. Approximately 10 seconds for each measurement will be needed. Subsequently, if the size of the tissue will allow it, the circular probe will be inserted in the tumor parenchyma at the same penetration depth and 10 cross sectional maps will be generated (approximately 30 seconds in total). Both information obtained using the linear and the circular probes will be integrated for a full characterization of the tissue under examination.
Interventions
DIAGNOSTIC_TESTResistivity measurement
To measure and compare the tissue impedance values obtained by analysing ex vivo non-neoplastic (healthy and peritumoral) and neoplastic breast tissues
Sponsors
Politecnico di Milano
Clinical Trial Unit Ente Ospedaliero Cantonale
Ente Ospedaliero Cantonale, Bellinzona
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Inclusion criteria
* Age \>18 years * First radiological diagnosis of breast adenocarcinoma needing a histological confirmation * Written Informed Consent
Exclusion criteria
* Tumor mass diameter \< 1 cm * Surgical specimen (harbouring tumoral + peritumoral tissue) diameter \< 2 cm
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Breat tissue characterization | 30 minutes from surgery | Use of Electrical Impedance Spectroscopyuse (EIS) to characterize ex vivo non-neoplastic (healthy and peritumoral) and neoplastic breast tissues |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Evaluation of the precision of each EIS measurement | 30 minutes from surgery | To evaluate the precision of each EIS measurement (healthy, peritumoral, cancerous) performed by the tissue impedance analyser in the same subject |
| Correlation between electrical and biological results | 30 minutes from surgery | To correlate the electrical behaviour of the breast cancer tissue to pathological and biological information |
Countries
Switzerland
Outcome results
None listed