Alveogyl and Gelatin Sponge in the Management of Pain After Epithelialized Free Gingival Graft Harvesting

Clinical Comparison of Alveogyl and Gelatin Sponge in the Management of Pain After Epithelialized Free Gingival Graft Harvesting: A Randomized Clinical Trial

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03402321

Enrollment

36

Registered

2018-01-18

Start date

2019-04-01

Completion date

2019-07-01

Last updated

2019-02-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain, Procedural

Keywords

alveogyl, gelatin sponge, free gingival graft, palate, pain

Brief summary

clinical comparison between alvogyl and gelatin sponge when used to protect the denuded area of the palatal donor site after free gingival graft in means of reducing pain and healing.

Interventions

DRUGGelatin Sponge Sheet

sheets act as a mechanical barrier used to protect the denuded area of the palatal donor site

paste form with analgesic action to protect the palatal donor site and help to relief pain

Sponsors

Karim ehab gerges

Lead SponsorOTHER

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Healthy volunteers

Yes

Inclusion criteria

1. Patients scheduled for different periodontal and peri-implant plastic surgeries requiring palatal mucosal graft harvesting 2. Systemically healthy

Exclusion criteria

1. Severe gagging reflex 2. Smokers 3. Occlusal trauma at site of graft 4. Pregnancy 5. Psychiatric disorder 6. Patients allergic to the used agents

Design outcomes

Primary

Measure	Time frame	Description
pain score	2 weeks	recorded by the pain trough a Visual Analogue scale score (between 0 and 10. 0: no pain, 1: minimal pain,10: severe pain)

Secondary

Measure	Time frame	Description
healing	4 weeks	healing of the palatal mucosa using H2O2 Test this test is based on the principle that if the epithelium is discontinuous, then H2O2 diffuses into the CT, the enzyme catalase acts on H2O2to release water and oxygen. This is shown clinically by the production of bubbles on the wound. The area to be evaluated is then dried, and 3% H2O2 is sprinkled on the wound with a syringe, waiting for the appearance of bubbles, which will suggest that the surgical site is not completely epithelialized. Complete healing will be recorded as a dichotomous variable (yes/no).
bleeding	2 weeks	Questionaire, Binary (yes or no).
analgesic consumption	2 weeks	questionaure, Numerical, Amount of analgesics daily consumption

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 28, 2026