Effects of Total Parenteral Nutrition on Skeletal Muscle Genomics.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03401944

Enrollment

Registered

2018-01-17

Start date

2005-01-01

Completion date

2014-12-31

Last updated

2018-01-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Wasting;Muscle(S)

Brief summary

The study investigates effects related to muscle protein metabolism at provision of Total Parenteral nutrition.

Detailed description

Randomized study investigating alterations in muscle protein metabolism at provision of parenteral nutrition. The study uses a genomic/transcriptomic/proteomic approach to evaluate factors related to activation of skeletal muscle protein synthesis. Patients scheduled for major gastrointestinal surgery are included. Muscle specimens are collected during surgery.

Interventions

DRUGTPN

OTHERControl

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

20 Years to 85 Years

Healthy volunteers

Inclusion criteria

* Major gastrointestinal surgery * Assumed need of post-operative artificial nutrition.

Exclusion criteria

* Insulin dependent diabetes * Steroid medication

Design outcomes

Primary

Measure	Time frame	Description
Muscle protein metabolism	Single evaluation point at 12-14 hours following the start of overnight infusion.	Alterations in muscle protein metabolism will be assessed by various standard techniques for gene and protein expression. Combined measurements of cell-signaling molecules representing anabolic and catabolic signaling pathways will be evaluated in relation to transcription of muscle myosin proteins.

Countries

Sweden

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026