Liver Metastases
Conditions
Brief summary
Patients will be imaged with MRE at the time of the RT planning MRI, prior to the induction of RT and immunotherapy. Research imaging will be in addition to standard imaging studies performed at time points consistent with the standard of care (at the time of the RT planning MRI and the first clinical follow-up). An additional MRE exam will be performed at the end of treatment outside the standard of care imaging.
Interventions
rapidly developing technology for quantitatively assessing the mechanical properties of tissue, using externally applied mechanical waves
Sponsors
Mayo Clinic
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* Age ≥ 18 years * Diagnosis of solid cancers with the presence of one or more liver metastases * Minimum metastasis diameter ≥ 2 cm * Planning to receive radiation therapy with immunotherapy * Willingness to participate in mandatory imaging studies at Mayo Clinic Rochester
Exclusion criteria
* Contraindications for MRI including claustrophobia, pace maker, metal implants, aneurism clips * Patients who are not able to consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quantify tissue mechanical properties of the liver and liver tumor using MRE in patients receiving radiation therapy + immunotherapy at baseline, mid-treatment and time of followup imaging determined by standard of care to assess response to therapy | 1 year |
Countries
United States
Outcome results
None listed