Airway Morbidity, Anesthesia, Safety Issues
Conditions
Keywords
preoxygenation, high flow oxygen
Brief summary
High flow nasal cannula oxygen has been proposed to perform preoxygenation in patients with acute respiratory failure requiring orotracheal intubation in intensive care units. However, its use for preoxygenation before the induction of general anaesthesia in operating room has never been evaluated in term of end tidal oxygen fraction which is the gold standard measurement during preoxygenation before general anaesthesia. The goal of the present study is to measure end tidal oxygen after 3 min of preoxygenation using the recommended method (spontaneous breathing of 100% inhaled oxygen through a face mask) and using high flow nasal canula oxygen, in healthy volunteers.
Detailed description
High flow nasal cannula oxygen has been proposed to perform preoxygenation in patients with acute respiratory failure requiring orotracheal intubation in intensive care units. The results suggest that high flow oxygen could be superior to bag reservoir face mask in term of occurrence of severe hypoxemia during the intubation procedure. At the present time its use for preoxygenation before the induction of general anaesthesia in operating room has never been evaluated in term of end tidal oxygen fraction which is the gold standard measurement ensuring that the functional residual capacity has been filled with oxygen. We planned a randomised cross over study in healthy volunteers studying efficacy and tolerance of preoxygenation using spontaneous ventilation with 100% inhaled oxygen through a face mask connected to the anaesthesia machine and preoxygenation using high flow nasal cannula oxygen (60l/min).
Interventions
PROCEDUREpreoxygenation
spontaneous breathing
Sponsors
University Hospital, Caen
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* healthy volunteers, * signed contentment
Exclusion criteria
* any chronic or acute disease, * pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| FeO2 at 3 min | 3 minutes | end tidal oxygen fraction measured through a gas analyser |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| time to obtain an FeO2 at 90% | 6 minutes | time to obtain an end tidal oxygen fraction measured at 90% measured through a gas analyser |
| proportion of adequate preoxygenation at 3 min | 6 minutes | proportion of adequate preoxygenation (FeO2=90%) at 3 min |
| tolerance | 1 hour | self reported tolerance on a likert scale |
| tolerance on VAS | 1 hour | self reported tolerance on a visual analogue scale |
Countries
France
Outcome results
None listed