Gait Disorders in Patients With Cognitive Decline

Correlation Between Gait Disorders and Neuropsychological Profile in Patients With Alzheimer's Disease and Lewy Body Disease

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03399591

Enrollment

100

Registered

2018-01-16

Start date

2017-05-02

Completion date

2019-03-31

Last updated

2018-07-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gait Disorders, Neurologic

Keywords

Gait Disorders, Spatio-temporal parameters of walking, Alzheimer's disease, Lewy body disease

Brief summary

The prevalence of neurodegenerative diseases will increase over the next decades driven by ageing population. It seems important to develop reliable, replicable and accessible diagnostic tools. This is a prospective study whose objective is to study the spatio-temporal parameters of gait in patients with Alzheimer's and Lewy body diseases. 64 patients were included in this study. A comparison of the two pathologies was conducted, followed by an analysis based on four groups (mild, severe Alzheimer's disease, mild, severe Lewy body disease) and a study of the severity of the diseases. To study these parameters, we used the Gaitrite treadmill. The analysis of spatio-temporal parameters of walking in Alzheimer's disease and Lewy body disease enables to identify discriminating variables between the two pathologies. The probability of suffering from an Alzheimer's disease decreases with the pace increase but increases with variations in length of the step, and with the rotation of the foot. While the probability of suffering from Lewy body disease increases with the pace, variations in the step duration, and the duration of double support. These results are interesting but do not allow to establish a diagnostic score for these two diseases. The monitoring of the variations of these parameters at individual level would probably be more relevant and would enable to detect dual pathologies.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

50 Years to No maximum

Inclusion criteria

* Patient over 50 * Hospitalized patient in day hospital * Patient with an etiological diagnosis of his cognitive disorder * Patient having a neuropsychological assessment * Patient able to walk without technical help * Patient having agreed to participate in the study

Exclusion criteria

\- Refusal to participate in the study

Design outcomes

Primary

Measure	Time frame
walking test	1 hour after inclusion

Countries

France

Contacts

Primary ContactJérémie PERISSE, MD

jeremie.perisse@chru-strasbourg.fr33 3 88 11 55 11

Backup ContactCandice Muller, MD

candice.muller@chru-strasbourg.fr33 3 88 11 55 11

Outcome results