Aging, HIV-1-infection
Conditions
Keywords
Exercise training, Intervention, Aerobic capacity
Brief summary
The study objective was to determine the safety and efficacy of aerobic exercise in older HIV-infected men in a randomized trial comparing different levels of exercise intensity.
Detailed description
The study was a randomized trial of moderate-intensity versus high-intensity aerobic exercise (AEX) training in older HIV-infected adults. Funding was provided by K23 AG024896 (PI, Oursler) and the UMB Claude D. Pepper Older Americans Independence Center P60 AG12583 (PI, Goldberg). The central hypothesis was that high-intensity AEX training is well-tolerated and significantly increases aerobic capacity in older HIV-infected adults. The study met its objectives: 1. Scientific AIMS met: 1. High-intensity AEX training significantly increases aerobic capacity 2. Both moderate-intensity and high-intensity AEX training improve ambulatory function and endurance. 3. Activity of skeletal muscle oxidative enzymes is reduced, and associated with aerobic capacity. 2. Feasibility Objectives met: 1. AEX training is safe and well-tolerated in older HIV-infected adults. 2. Skeletal muscle punch biopsy is safe and well-tolerated in older HIV-infected adults. 3. Preliminary data was collected on plasma biomarkers of inflammation.
Interventions
BEHAVIORALExercise training
Participants attended center-based exercise sessions three times per week at the research exercise training facility located at the Baltimore VA Medical Center. All exercise training was performed under the supervision of research exercise physiologists. Heart rate (HR) was measured continuously during each session using a Polar HR watch and chest strap allowing for assessment and maintenance of treatment fidelity. Exercise logs included details on exercise type, duration, time in target heart rate zone, blood pressure and perceived intensity during each training session.
Sponsors
University of Maryland, Baltimore
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
DOUBLE (Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
50 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* HIV+ * stable combination antiretroviral therapy (cART)
Exclusion criteria
* AIDS defining conditions in the prior six months * Conditions that increase the risk of exercise training per the American College of Sports Medicine (ACSM)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline Cardiorespiratory Fitness at 16 weeks | 16-weeks | Cardiorespiratory Fitness measured by VO2peak |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline Six-minute walk distance at 16 weeks | 16-weeks | Distance walked at normal pace in 6 minutes |
| Change from baseline body composition at 16 weeks | 16-weeks | body composition measured as total and regional lean tissue and fat mass (DXA) |
| Change from baseline exercise endurance at 16 weeks | 16-weeks | exercise endurance measured as time on treadmill during modified Bruce protocol |
Other
| Measure | Time frame | Description |
|---|---|---|
| skeletal muscle oxidative function | baseline | activity of enzymes in oxidative function from muscle biopsy |
Outcome results
None listed