Effect of Low Tidal Volume on Blood Loss During Laparoscopic Hepatectomy

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03399123

Enrollment

104

Registered

2018-01-16

Start date

2017-04-01

Completion date

2018-10-30

Last updated

2018-01-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Blood Loss

Keywords

Laparoscopic hepatectomy, Low tidal volume, Blood loss

Brief summary

To explore the effect of low tidal volume on blood loss and gas exchange during laparoscopic hepatectomy

Detailed description

Background & Aims:Liver cancer is an disease that threatening human health .Laparoscopic hepatectomy is more and more widely used.It is very important to reduce the bleeding during laparoscopic hepatectomy.The investigators found that low tidal volume can effectively reduce intraoperative bleeding.The aim of this study was to explore the effect of low tidal volume on blood loss and gas exchange during laparoscopic hepatectomy

Interventions

OTHERTidal volume

After General anesthesia, patients that during volume control mode of mechanical ventilation in experimental group, we take low tidal volume.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

TRIPLE (Subject, Caregiver, Outcomes Assessor)

Intervention model description

Two different tidal volume are conducted on the participant base on the randomized choices

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

1. Aged from 18 to 70 years old; 2. American association of anesthesiologists(ASA) score I to III; 3. Ability to adhere to the study schedule; 4. Ability to provide informed consent and complete all study assessments; 5. Patients undergoing selective surgery of laparoscopic hepatectomy.

Exclusion criteria

1. The New York Heart Association classification(NYHA) III to IV; 2. Chronic obstructive pulmonary disease,respiratory failure, patients after thoracic surgery. 3. BMI\>32Kg/m2; 4. Abnormal in blood coagulation function; 5. Patients with mental disease; 6. Patients with neuromuscular disease; 7. Concurrent enrollment in another Randomized controlled trial(RCT); 8. Absence of written informed consent.

Design outcomes

Primary

Measure	Time frame	Description
Blood loss	through study completion, an average of 48hours	Blood loss during operation.

Secondary

Measure	Time frame	Description
central venous pressure	During operation	The central venous pressure(CVP)during operation
mean arterial pressure	During operation	The mean arterial pressure(MAP)during operation
oxygenation index	During operation	The oxygenation index during operation.

Countries

China

Contacts

Primary ContactNing Jiaolin

Njiaolin1976@126.com0086-15808014085

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026