Chronic Inflammatory Demyelinating Polyneuropathy, Charcot-Marie-Tooth Disease, Type IA, Anti-MAG Neuropathy
Conditions
Brief summary
This project aims to understand how nerve mechanical properties are altered in patients with rare peripheral neuropathies . Stiffness of various peripheral nerves will be measured using ultrasound shear wave elastography. Patients will be compared with age-matched controls.
Detailed description
The following nerve will be studied bilaterally, in a randomised order: Median, ulnar, Radial, Sciatic and Tibial. Participants will be asked to remain relaxed during elastography measurements.
Interventions
elastography measurements
Sponsors
Université de Nantes
Nantes University Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Male or female aged 18 to 65 * Having social insurance status * Having given informed consent * Diagnostic of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), CMT1a or Anti-MAG (peak immunoglobulin M (IGm)\>15,000 BTU)
Exclusion criteria
For controls: * Person staying in a health or social facility * Person unable to understand the protocol and to respect the modalities * Person deprived of liberty * Person of legal age benefiting from a system of legal protection (guardianship, curators or safeguard of justice) * Participation in another biomedical research in progress * Diabetes, history of neuromuscular disease For CIDP: * Person staying in a health or social facility * Person unable to understand the protocol and to respect the modalities * Person deprived of liberty * Person of legal age benefiting from a system of legal protection (guardianship, curators or safeguard of justice) * Participation in another biomedical research in progress * MRC score \< 3 For Charcot-Marie-Tooth type 1 (CMT1) and anti-MAG: * Person staying in a health or social facility * Person unable to understand the protocol and to respect the modalities * Person deprived of liberty * Person of legal age benefiting from a system of legal protection (guardianship, curators or safeguard of justice) * Participation in another biomedical research in progress
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| nerve shear wave velocity | Day0 | Ultrasound shear wave elastography will provide a measure of nerve shear wave velocity, which will be used as a surrogate of nerve stiffness. |
Countries
France
Outcome results
None listed