Losartan and Emotion Processing

Losartan Effects on the Extinction of Conditioned Fear in Humans

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03396523

Enrollment

Registered

2018-01-11

Start date

2018-01-04

Completion date

2018-12-31

Last updated

2018-06-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

Losartan, Fear extinction

Brief summary

The aim of the study is to investigate the effect of losartan (50mg, single dose) on the extinction of conditioned fear

Detailed description

In a double-blind, between-subject, placebo controlled design the effects of a single dose of losartan (50mg) on fear extinction in healthy male participants will be examined. Participants will initially undergo a Pavlovian fear conditioning procedure, followed by the administration of 50mg losartan or placebo. 90 minutes after treatment subjects will undergo the fear extinction procedure. Neural activity and psychophysiological indices of arousal will be assessed by the simultaneous acquisition of functional magnetic resonance imaging (fMRI) and skin conductance data.

Interventions

DRUGLosartan

administration of losartan (50 mg) (oral)

DRUGPlacebo Oral Tablet

administration of placebo (oral)

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

MALE

Age

18 Years to 30 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy subjects without past or current psychiatric or neurological disorders

Exclusion criteria

* history of head injury * medical or psychiatric illness * hypertension

Design outcomes

Primary

Measure	Time frame	Description
Losartan effects on neural activity during fear extinction	1 hour	Neural activity will be measured by functional magnetic resonance imaging (fMRI). Effects of treatment will be evaluated by comparing extinction-related neural activity in the core extinction network (prefrontal cortex, limbic regions) between the active treatment and the placebo group.

Secondary

Measure	Time frame	Description
Losartan effects on skin conductance responses during fear extinction	1 hour	Effects of treatment will be evaluated by comparing extinction-related skin conductance responses between the active treatment and the placebo group.

Countries

China

Contacts

Primary ContactWeihua Zhao, Master

zarazhao.uestc@outlook.com86-28-61830811

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026