A Cohort Analysis Study of Intestinal Flora in Infants

An Observational Study of Intestinal Flora in Infants

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03396198

Enrollment

100

Registered

2018-01-10

Start date

2017-12-22

Completion date

2020-12-22

Last updated

2020-07-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastrointestinal Microbiome

Keywords

Gastrointestinal Microbiome, Infants

Brief summary

The purpose of this study is to investigate the influence factors of gastrointestinal microbiome in infants.

Detailed description

The gastrointestinal microbiome is believed to be critically important for infant growth and development. As we all know, the gut microbiota can influence gut maturation, metabolic, immune and brain development in early life. Host genotype, gestational age, antibiotic use, mode of delivery, diet and the context in which the infant is born (rural vs urban, presence of siblings, pets and other factors) can influence the development of infant gut microbiota. In the early life stage, intestinal flora disorders may alter the host immune function and increase the susceptibility to immune or metabolic diseases. This research intends to establish a birth cohort of healthy newborns. The influence factors of gastrointestinal microbiome will be investigated by means of questionnaire survey, specimen collection and high throughput sequencing analysis. What's more, the correlation of gut microbiome, infant growth as well as related diseases will be explored either. The results will provide constructive suggestions for the establishment of infant normal intestinal flora and play an indispensable role in exploring the occurrence, development and prevention of related diseases.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

No minimum to 3 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy newborns

Exclusion criteria

* Newborns with diseases such as congenital heart disease or congenital malformation and so on

Design outcomes

Primary

Measure	Time frame	Description
Intestinal Flora Sequencing	Intestinal Flora Sequencing Change from Baseline to 12 months after Birth	Intestinal Flora Sequencing

Countries

China

Contacts

Primary ContactMizu Jiang, Doctor

mizu@zju.edu.cn+8613857107171

Outcome results