Pulmonary Disease
Conditions
Keywords
bronchoscopy, conscious sedation, fentanyl, Bispectral Index
Brief summary
Fentanyl is analgesia medication. There has not pain nerve in the lung. Flexible bronchoscopy(FB) is used in the respiratory medicine. So people will not feel pain in the process of FB. The purpose of the study is to know if Fentanyl is useful in the conscious sedation of FB.
Detailed description
Fentanyl is opioid receptor agonists. It is a fast-acting, short duration and potent analgesics. Flexible bronchoscopy (FB) is mostly used in the diagnosis and therapy in the respiratory disease. As we know, there has not pain nerve in the lung. People will not feel pain when they are in FB. If fentanyl will be effective in FB? Our study will observe the effect of conscious sedation in FB with fentanyl or without fentanyl.
Interventions
DRUGFentanyl
Five minutes before the patients is done the flexible bronchoscopy, fentanyl will be intravenous injected.
DRUGMidazolam
Five minutes before the patients is done the flexible bronchoscopy, midazolam will be intravenous injected.
DRUGPropofol
Propofol will be intravenous injected as soon as the flexible bronchoscopy begins.
Bispectral Index monitoring will be used in the process of the flexible bronchoscopy.
Sponsors
Nanjing First Hospital, Nanjing Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
Cough reflex is good agree to do bronchoscopy agree to take part in the study no the contraindication of bronchoscopy
Exclusion criteria
Forced expiratory volume in one second\<1 L severe hemoptysis severe heart, liver,kidney failure psychiatric and nervous disorders allergic to the anesthetic ( fentanyl, midazolam, or propofol)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| perioperative changes of blood pressure | every 5 minutes from the operation beginning to end | For each patient,bispectral index monitoring after anesthesia. Bp will be measured. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Patient satisfaction rate | One day after the operation | One day after the patient do the bronchoscopy, ask him/her about the satisfaction to the operation |
| perioperative time | from the operation beginning to end | For each patient, record the time bronchoscopy in and out |
| Adverse events | in the process of the operation | For each patient, Adverse events (overall intraoperative cough,bleeding,low oxygen solution) will be record in the operation |
Outcome results
None listed