Wound Infiltration With Ketorolac Versus Lidocaine for Postoperative Analgesia After Total Abdominal Hysterectomy

Wound Infiltration With Ketorolac Versus Lidocaine for Postoperative Analgesia After Total Abdominal Hysterectomy: a Prospective, Randomized, Double-blind Study.

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03394001

Enrollment

Registered

2018-01-09

Start date

2018-01-01

Completion date

2018-06-30

Last updated

2018-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia

Brief summary

The main goal of this study is to compare wound infiltration with ketorolac versus lidocaine for postoperative analgesia in total abdominal hystrectomy (TAH) operation.

Interventions

PROCEDUREWound infiltration

Before skin closure,the subcutaneous tissue and skin all around the wound will be infiltrated by 20 mL of the drug then closure of the skin will be done.

DRUGLidocaine Hydrochloride

20 ml of 1% Lidocaine solution

DRUGKetorolac tromethamine

20 mL of saline with 30 mg ketorolac

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

FEMALE

Age

20 Years to 60 Years

Healthy volunteers

Inclusion criteria

* ASA physical status I and II * Planned for elective TAH with a Pfannenstiel incision

Exclusion criteria

Patients with the following criteria will be excluded from the study; * ASA physical status more than II * Body mass index (BMI)\>35 kg/m2 * Previous abdominal surgeries * Malignancy * Individuals with chronic pain * A history of severe systemic disease * A pre-existing neurological or psychiatric illness * Known to be addict on alcohol or drugs * Known allergy to the study drugs

Design outcomes

Primary

Measure	Time frame	Description
Rescue analgesia time	First 24 hours postoperatively	Time for first analgesia requirement

Secondary

Measure	Time frame	Description
Patient's pain score	First 24 hours postoperatively	Pain score will be done by visual analog scale (VAS) (minimum 0 = no pain, while maximum 10 cm = worst possible pain). Pain score will be recorded just after extubation (taken as 0 h) and after 1, 2, 4, 6, 12, 18 and 24 h later. Patients will be instructed about the usage of VAS scalebefore the operation.
The total analgesic consumption	First 24 hours postoperatively	Postoperative analgesia will be provided with intramuscular (IM) meperidine 50 mg to both groups when the VAS score is ≥4. The total meperidine consumption will be recorded.

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026