Respiratory Variations of the Diameter of Superior Vena Cava for Predicting Fluid Responsiveness After Cardiac Surgery

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03393897

Enrollment

Registered

2018-01-09

Start date

2018-01-03

Completion date

2018-10-31

Last updated

2018-12-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Transesophageal Echocardiography, Vena Cava Superior

Keywords

fluid responsiveness, cardiac surgery

Brief summary

In a recent study (Vignon 2017), respiratory variations of the diameter of superior vena cava had a greater diagnostic accuracy than pulse pressure variations and inferior vena cava respiratory variations in 540 medical and surgical ICU patients. But this indicator has not been investigated yet in cardiac surgery. The investigator aim to study respiratory variations of superior vena cava for predicting fluid responsiveness after cardiac surgery. In post-operative cardiac surgery patients with hemodynamic failure, the investigator will measure respiratory vena caval variations with TEE (Trans oesophageal echocardiography). Then, the investigator will evaluate fluid responsiveness after a fluid challenge (Trendelenburg). A ROC curve will be constructed in order to assess the optimal sensitivity and specificity of this parameter.

Interventions

OTHERTrans oesophageal echocardiography

Transoesophageal echocardiography : it's a standard practice for this patient

OTHERTrendelenburg test

Trendelenburg test : it's a standard practice for this patient

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Hemodynamic instability with hypotension, * Low cardiac output or norepinephrine requirements in the first 6 post-operative hours.

Exclusion criteria

* TEE (Trans oesophageal echocardiography) contra-indication * Trendelenburg contra-indication

Design outcomes

Primary

Measure	Time frame	Description
diameter of vena cava superior	at 6 post-operative hours	measured with trans oesophageal echocardiography

Secondary

Measure	Time frame	Description
% of respiratory variations of maximal Doppler velocity in left ventricular outflow tract	at 6 post-operative hours	measured with trans oesophageal echocardiography
% of respiratory variations of maximal Doppler velocity in pulmonary artery	at 6 post-operative hours	measured with trans oesophageal echocardiography
% of pulse pressure respiratory variations	at 6 post-operative hours	measured with trans oesophageal echocardiography

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026