Preoperative Pain and POCD in Elderly Patients

Preoperative Chronic Pain Increases the Risk of Early Postoperative Cognitive Dysfunction in Elderly Patients Undergoing Hip Joint Replacement Surgery: a Prospective Observational Cohort Study

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03393676

Enrollment

100

Registered

2018-01-08

Start date

2018-01-10

Completion date

2020-03-31

Last updated

2020-03-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Cognitive Dysfunction

Keywords

Postoperative Cognitive Dysfunction, elderly patients, Preoperative Pain

Brief summary

The purpose of this study is to investigate whether preoperative pain is the risk factor of POCD in elder patients.

Detailed description

Postoperative cognitive dysfunction (POCD) occurs mainly in aged patients. The mechanism of POCD is not clear yet and no effective therapy method. In the present study, we conducted a single-center observational prospective cohort trial in elder patients who undergoing hip joint replacement surgery with general anesthesia to test our hypothesis that preoperative chronic pain is one of the risk factors of POCD after major joint replacement surgery.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

65 Years to No maximum

Healthy volunteers

Inclusion criteria

1. Elder than 65 years old 2. Speak Chinese Mandarin 3. Those who will undergo major low limb surgery like hemiarthroplasty or total hip arthroplasty with general anesthesia. 4. Signed the inform consent 5. American Society of Anesthesiologists classification I to II

Exclusion criteria

1. Existing cerebral disease, or have a history of neurological and psychiatric disease including Alzheimer Disease, stroke, epilepsy and psychosis 2. Existing cognitive impairment as evidenced by Mini-Mental State Examination scores below 24 3. Severe hearing or visual impairment 4. Unwillingness to comply with the protocol or procedures 5. Cannot communicate with Chinese Mandarin 6. Serious pulmonary, heart , liver or renal insufficiency patients 7. Had anesthesia or surgery within the past 30 days

Design outcomes

Primary

Measure	Time frame	Description
POCD incidence 7 days (or before leaving hospital) after surgery	7 days (or before leaving hospital)	POCD incidence 7 days (or before leaving hospital) after surgery

Secondary

Measure	Time frame	Description
POCD incidence 2 months after surgery	2 months after surgery	POCD incidence 2 months after surgery

Countries

China

Contacts

Primary ContactXiaorong Huai, MS

smile_huai@126.com13818003683

Backup ContactDiansan Su, MD

diansansu@yahoo.com18616514088

Outcome results