Sore Throat
Conditions
Keywords
muscle relaxant
Brief summary
Investigators assess and compare postoperative sore throat and hoarseness in the group maintaining moderate relaxation and deep relaxation during operation.
Detailed description
In this sturdy, the deep block is applied when the surgeon requests for deep muscle relaxation to improve surgical field condition in the surgery such as laparotomy known that the deep block is helpful and in the other surgeries, the moderate block is maintained. The investigators assess the postoperative sore throat and hoarseness and compare the effect of muscle relaxation depth in the deep block group and moderate block group in terms of the incidence and severity of postoperative sore throat and hoarseness.
Interventions
DRUGRocuronium(deep)
In the group with deep relaxation during surgery, rocuronium is given by continuous infusion (0.6 mg/kg/h).
DRUGRocuronium(moderate)
In the group with deep relaxation during surgery, rocuronium is given by bolus dose(0.15mg/kg) induced a train of four count of 1-2.
Sponsors
SMG-SNU Boramae Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Requirement for mechanical ventilation under general anesthesia
Exclusion criteria
* Hoarseness and sore throat existed before surgery * Upper respiratory infection * Known or predicted difficult airway * Liver, renal disease * Requirement of postoperative ventilator care * the operation within 2hrs * Laparoscopic surgery * Other positions except supine during surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Overall incidence of postoperative sore throat | Within 24 hrs after operation | The overall cumulative incidence of postoperative sore throat is assessed in the 24-hr evaluation period |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The incidence of postoperative sore throat | At 1,6, and 24 hrs after operation | The presence of sore throat is assessed. |
| The severity of postoperative sore throat | At 1,6, and 24 hrs after operation | The severity of sore throat is assessed by using a 100-point numerical ratig scale (NRS, 0 \[no pain\], 100 \[worst pain imaginable\]). |
| Incidence and severity of postoperative hoarseness | At 1,6, and 24 hrs after operation | Hoarseness is defined as a voice quality different from the preoperative voice and graded as follows: none (no hoarseness), mild (recognized by the patient), moderate (obvious to the investigator), and severe (aphonia). |
| Postoperative analgesic consumption | Within 24 hrs after operation | The amount of patient-controlled analgesia and other analgesic medication used |
Countries
South Korea
Contacts
Primary ContactJee-Eun Chang, M.D
Outcome results
None listed