Low Tension Glaucoma
Conditions
Brief summary
The study includes Caucasian patients with diagnosis of normal tension glaucoma and age- and sex-matched healthy individuals. Measurements of optic nerve head blood flow will be performed with laser speckle flowgraphy (LSFG). Also, the intraocular pressure (IOP), systolic and diastolic blood pressure, heart rate (HR), mean arterial pressure (MAP) as well as ocular perfusion pressure (OPP) will be evaluated. After baseline measurements individuals will be asked to ingest 800 ml of water in less than five minutes. Measurements will be repeated after 15, 30 and 45 minutes.
Interventions
PROCEDUREWater drinking test
Ingestion of 800 ml water in less than 5 minutes.
Sponsors
Augenabteilung Allgemeines Krankenhaus Linz
Study design
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
40 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* presence of glaucomatous optic disc changes in biomicroscopy and visual field defects or abnormal circumpapillary retinal nerve fibre layer (RNFL) thinning (evaluated by OCT as defined by the on-board software) * IOP ≤ 21mmHg without therapy * normal open angle in a gonioscopic examination * age \> 40 years
Exclusion criteria
* IOP \> 21 mmHg in patients' history * ametropia \> 6 diopters * cataract with severity greater than grade 2 of the lens opacities classification system (LOCS) classification * presence of corneal opacities * uncontrolled hypertension with systolic blood pressure (SBP) \> 165mmHg and/or diastolic blood pressure (DBP) \> 100mmHg
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in ONH blood flow induced by water drinking test | baseline, after 15, 30 and 45 minutes | ONH blood flow evaluated by laser speckle flowgraphy |
Countries
Austria
Outcome results
None listed