Infection, Liver Cirrhosis, Vitamin D Deficiency
Conditions
Brief summary
It is widely known that vitamin D has an important role in calcium metabolism and bone mineralization. Its deficiency is related to rickets and osteomalacia in children and adults respectively. Vitamin D had a role in innate and acquired immunity. It increases innate defense and modulates lymphocytes activation, leading to a change toward a T2 helper response ). The role of vitamin D deficiency on the risk of bacterial infection among patients in intensive care units has been reported. An observational studies in children reported an association between low 25-OH vitamin D level and infectious viral diseases . The deranged metabolism of vitamin D in liver cirrhosis was first reported in the late '70s and was attributed mainly to impaired 25(OH)-vitamin D hydroxylation of the precursor vitamin D caused by impaired liver function. Low level of vitamin D was found independently to be associated with increased risk of bacterial infections in patients with liver cirrhosis. The observed relationship between the lack of vitamin D and the increase risk of mortality in cirrhotic patients could be attributed to bacterial infections. Thus, the association of low vitamin D levels with liver insufficiency and infections supports the use of vitamin D as a prognostic marker in the population of cirrhosis. Studies on the role of vitamin D as a risk factor for infections in patients with liver cirrhosis are not well studied in our locality(Upper Egypt).
Interventions
DIAGNOSTIC_TEST3- Serum 25-Hydroxy Vitamin D level will be measured by Competitive ELISA technique
Serum 25-Hydroxy Vitamin D level will be measured by Competitive ELISA technique using CALBIOTECH (A life science company) kit, Catalog No.: VD220B
Sponsors
Assiut University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Admitted patients with liver cirrhosis irrespective of the underlying etiology during 6 months in Al Rajhi Liver Hospital, Assiut, Egypt who accept to participate in the study
Exclusion criteria
* Patients with cholestatic liver disease, patients receiving antibiotics to treat their infection prior hospital admission and patients refusing to participate in the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Vitamin D deficiency as a risk factor for infection in cirrhotic patients | 6 month | Measurement of Vitamin D levels in cirrhotic with infection when compared with cirrhotic without infection and determination of Vitamin D level cut-off points for infection in cirrhotic patients |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Correlation of Vitamin D level with Liver Disease severity | 6 month | Correlation of Vitamin D level with Child Pugh Grade |
| Correlation of vitamin D level with liver disease severity | 6 month | Correlation of Vitamin D level with MELD score |
| Determination of independent predictor of infection in cirrhotics | 6 month | Use of logistic regression analysis for risk factors for infection in cirrhotic patients |
Countries
Egypt
Contacts
Primary ContactHaidi K Ramadan, M.D
Outcome results
None listed