Efficacy of Low Dose Levothyroxine During Pregnancy

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03391154

Enrollment

180

Registered

2018-01-05

Start date

2017-05-01

Completion date

2020-08-30

Last updated

2021-10-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Euthyroid Females

Brief summary

the effect using low dose levo thyroxine in pregnant females with TSH level more than 2.5 mU/L in the first trimester on pregnancy outcome

Detailed description

the study aim to detect the effect of low dose levothyroxine 50 ug on pregnant females and compare it with others receiving placebo

Interventions

DRUGlevothyroxin

90 female received levothroxine

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 40 Years

Healthy volunteers

Inclusion criteria

* females with TSH more than 2.5 mU/L and less than 4 mU/L after biochemical diagnosis of pregnancy.

Exclusion criteria

* associated endocrinopathies (PCO/ DM/ hyperprolactinemia ) * associated medical condition (HTN/ chronic kidney disease. * history of recurrent pregnancy loss

Design outcomes

Primary

Measure	Time frame	Description
1st trimester miscarriage	during 1st 13 weeks of pregnancy	1st trimester spontaneous or missed abortion

Secondary

Measure	Time frame	Description
adverse pregnancy outcome	last 26 week of gestation	2nd trimesteric missed or spontaneous abortion ,gestational hypertension,preeclampsia, anemia, abruptio placenta premature delivery , fetal growth restriction, low birth weight

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026