Lower Respiratory Tract Infection
Conditions
Brief summary
LRTI (Lower respiratory tract infection) is a severe disease in China. The fast and accurate diagnosis of pathogens, bacteria or viruses that cause the infection is critical for the therapy. In this study, investigators assume that the use of FilmArray Respiratory Panel will provide more rapid and comprehensive evidences to physicians to diagnose LRTI which is caused by viruses or atypical pathogens and then reduce the length of antibiotics use by 0.5-1.0 days as well as other hospital resources (length of hospital/ICU stay, take-away oral antibiotics, etc.). Secondly, investigators assume that in LRTI patients with viral infection and a low serum PCT level, fewer length of antibiotics use can be expected. Thirdly, the use of FilmArray Respiratory Panel will provide clearer epidemiology data of virus and atypical pathogens in hospitalized LRTI patients.
Interventions
DIAGNOSTIC_TESTFilmArray Respiratory Panel
An Multi-PCR method which can detect 20 pathogens in 45 minutes.
Sponsors
BioMérieux
Bin Cao
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adults age \>= 18 years old * Community acquired Pneumonia, acute exacerbation of chronic obstructive pulmonary disease \[AECOPD\], acute exacerbation of bronchiectasis. * Hospitalization required * Informed Consent Form signed
Exclusion criteria
* Age \< 18 years old * Hospital acquired Pneumonia * Patients with lung tuberculosis * Pregnant women * Patients with immunodeficiency * Any conditions which may increase PCT levels * Informed Consent Form not signed
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The length (days) of antibiotics therapy in hospital between two groups. | From in-hospital to discharge or death, whichever came first, assessed up to 12 months | The duration of antibiotics used is defined as days of intravenous antibiotic therapy in which any doses of antibiotics are administered. |
Secondary
| Measure | Time frame |
|---|---|
| Antibiotics therapy cost | From in-hospital to discharge or death, whichever came first, assessed up to 12 months |
| Length of hospital stay (LOS) and/or ICU stay | From in-hospital to discharge or death, whichever came first, assessed up to 12 months |
| The correlation between the initial serum PCT level and clinical outcomes/mortality | From in-hospital to discharge or death, whichever came first, assessed up to 12 months |
| The detection rate of viruses and atypical pathogens by FilmArray in LRTI patients | From in-hospital to discharge or death, whichever came first, assessed up to 12 months |
Countries
China
Contacts
Primary ContactShengchen DUAN, doctor
Outcome results
None listed