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Microbial Profile Among Patients Before and After Partial Maxillectomy

The Microbial Profile Among Patients Before and After Partial Maxillectomy

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03390699
Enrollment
15
Registered
2018-01-04
Start date
2018-01-31
Completion date
2018-03-31
Last updated
2018-01-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Microbiology, Maxilla

Brief summary

Patients after maxillecotmy develop gum disease and teeth decay often. these two diseases are caused by bacteria. In addition, these patients may have oral infections such as candida . The therapeutic approach now days to these diseases (dental decay and periodontal disease) can change following the results of the study. the purpose of the study is to examine whether the connection between the oral cavity and anatomical structures exposed by maxillectomy procedure causes a change in the level of microbes examined. To the best of our knowledge, there are not yet studies examined the clinical and microbiological changes in the oral cavity before and after surgery.

Detailed description

This study will include 15 patients who are scheduled to undergo partial maxillectomy as part of a prescribed treatment program prior to their eligibility for the study. The patients will undergo the surgery at the Department of Otolaryngology or Oral and Maxillofacial Surgery and will be given an obturator during surgery by a physician from the Internal and Maxillofacial Rehabilitation Department of the School of Dentistry . demographic data on the patient's age and gender, general medical history, smoking habits, oral and periodontal and clinical examination (presence of periodontal disease) and microbiological testing will be preformed.

Interventions

DIAGNOSTIC_TESTMicrobial profile

microbiological testing

Sponsors

Rambam Health Care Campus
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE

Intervention model description

Microbial profile among patients before partial maxillectomy

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

1. signed Consent form 2. Patients who are supposed to undergo Maxilla removal without closing the defect using a tissue implant and will need to complete the missing area by an obturator. 3. Men and women aged 18 and over

Exclusion criteria

1. Allergy to substances from which the obturator is made. 2. Pregnant women 3. Taking antibiotic drugs that affect bacterial flora 4 weeks before taking the saliva sample. 4. Psychiatric problem

Design outcomes

Primary

MeasureTime frameDescription
microbial types6 monthstypes of microbes on the sliva

Contacts

Primary ContactZvi Gutmacher, DMD
z_gutmacher@rambam.health.gov.il972-47772983
Backup ContactIlan Hirsh, DMD
i_hirsh@rambam.health.gov.il972-47772983

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026