Misoprostol Versus Active Management of Labour in CS

Intrauterine Misoprostol With Active Management of Labour Versus Active Management of Labour for Prevebtion of Postpartum Hemorage in Cesarean Section ,Randomized Controlled Trial

Status

Completed

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03390010

Enrollment

300

Registered

2018-01-04

Start date

2017-12-28

Completion date

2018-03-06

Last updated

2022-11-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cesarean Section

Brief summary

Several treatment strategies are emplemented to prevent post delivery hemorage and decreasing maternal morbidity and mortality .

Detailed description

Many approved drugs are used in prophylaxis against postpartum hemorage from these medications are the (syntocinon combined with methergine ) that are known as active management of labour drugs . Moreover there is misotac , that also guards against postpartum hemorage . All these medications act in a different way to cause uterine contraction post delivery to prevent uterine atony . -Here we are comparing the additive value of misotac intrauterine to syntocinon and methergine in comparison to the usually used syntocinon plus methergine .

Interventions

DRUGMisoprostol + syntocinon and using extra uterotonic drugs when needed ; methergine

medical prophylaxis against postpartum atony and postpartum hemorage by giving misoprostol plus syntocinon and using extra uterotonic drugs when needed ; methergine, carboprost

DRUGSyntocinon and using extra uterotonic drugs when needed ; methergine carboprost

medical prophylaxis against postpartum atony and postpartum hemorage by giving syntocinon and using extra uterotonic drugs when needed ; methergine, carboprost

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 42 Years

Healthy volunteers

Yes

Inclusion criteria

* • All patients included in this research were aged 18-42 years, pregnant 37 weeks till 42 weeks * no medical disorders with pregnancy e.g DM, HTN. All patients were subjected to full history taking, examination.

Exclusion criteria

Design outcomes

Primary

Measure	Time frame
The number of participants who passed cesarean section without postpartum hemorage	within 2 days post CS

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026