Liver Fibroses
Conditions
Brief summary
This study is a multicenter individual patient-based meta-analysis that will assess the performances of liver stiffness measurements performed with supersonic shear imaging shearwave elastography (SSI-SWE) in patients with liver fibrosis to predict progression of chronic liver disease.
Interventions
DEVICEElastography
liver stiffness measurements by shear wave-based elastography
Sponsors
University of Bonn
SuperSonic Imagine
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients who had received a liver ultrasound exam at baseline for a suspected chronic fibrotic liver disease of viral and/or steatotic origin, * Patients who had reached the age of majority in their countries, at baseline, * Patients with a baseline liver biopsy for histological evaluation of liver fibrosis with a length ≥ 15 mm paraffin sections (except if cirrhosis), * Patients for whom a minimum length of clinical follow-up from baseline of 1 year had been recorded
Exclusion criteria
* Cause of chronic liver disease other than viral, ALD or NAFLD ( hemochromatosis, autoimmune hepatitis, biliary tract disease intrahepatic...) * Any systemic, viral hepatitis and HIV co-infection
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Liver disease progression rate | Minimum of 28 days follow-up | Clinical signs of liver decompensation |
| Mortality rate | Minimum of 28 days follow-up | Patient's death |
Outcome results
None listed