Endtidal Carbon Dioxide for Earlier Detection of Pulmonary Hypertension

Endtidal Carbon Dioxide for Earlier Detection of Pulmonary Hypertension in Patients With Suspicion of Pulmonary Hypertension

Status

Enrolling by invitation

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03388476

Acronym

EARLIER

Enrollment

500

Registered

2018-01-03

Start date

2018-05-02

Completion date

2035-01-01

Last updated

2022-05-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Thromboembolic Pulmonary Hypertension, Hypertension, Pulmonary, Hypertension;Pulmonary;Primary, Lung Diseases, Vascular Diseases

Keywords

pulmonary hypertension, endtidal co2, endtidal carbon dioxide, pulmonary arterial hypertension

Brief summary

Measurement of the endtidal carbon dioxide by capnography to exclude or to ensure the diagnosis pulmonary hypertension. The aim of the study is to obtain an endtidal carbon dioxide cut-off value for the diagnostic algorithm for pulmonary hypertension as an easily measurable and cheap diagnostic tool in patients with suspicion of pulmonary hypertension.

Detailed description

The disease pulmonary hypertension is due to a remodeling of the lung vessels which results in a change of the exhaled air. This change is measurable with a so called capnograph. The investigators want to measure the breath from patients with and without pulmonary hypertension to detect a cut-off value for the diagnosis pulmonary hypertension. Patients which have the probably diagnosis pulmonary hypertension and are older than 18 years are investigated. This patients will get an right heart catheterization and a measurement from their exhaled air.

Interventions

DIAGNOSTIC_TESTCapnography

Measuring of the exhaled air, especially endtidal co2, through capnography.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

Age \> 18 years, suspicion of pulmonary hypertension, planned or accomplished right heart catheterization

Exclusion criteria

none

Design outcomes

Primary

Measure	Time frame	Description
Measurement PetCO2	At baseline	Measurement PetCO2 by capnography at rest after or before a right heart catheterization, comparison of the parameter between patients with and without

Secondary

Measure	Time frame	Description
Establishing a cut-off	At baseline	Establishing a cut-off for the non-invasive diagnosing of pulmonary hypertension, which differs between patients with and without pulmonary hypertension and save patients without the disease before a dispensable invasive right heart catheterization

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026