Neurogenic Bladder, Overactive Detrusor
Conditions
Brief summary
The changes in bladder function after the injection of Onabotulinum toxin into the detrusor in individuals with neurogenic bladder overactivity will be investigated retrospectively. The records of all patients treated with Onabotulinum toxin injections into the detrusor since 2000 will be evaluated. The changes in the urodynamic values after the injection of 300 units of Onabotulinum toxin will be compared with the changes after the injection of 200 units. Furthermore, the differences in urinary continence, duration between injections, side effects and complications between the two groups will be investigated.
Interventions
DRUGInjection of Onabotulinum toxin
multiple injections of Onabotulinum toxin into the detrusor muscle
Sponsors
Swiss Paraplegic Research, Nottwil
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 99 Years
Healthy volunteers
No
Inclusion criteria
* neurogenic detrusor overactivity * spinal cord injury * Onabotulinum toxin injections into the detrusor from 2000-2017
Exclusion criteria
* missing urodynamic values before or after Onabotulinum toxin injections
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| change in detrusor pressure post-injection | within 3 months before injection; within 2 months after injection | bladder detrusor pressure during storage phase |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| bladder compliance | within 3 months before injection; within 2 months after injection | The relationship between a change in bladder volume and the change in detrusor pressure (ΔDV/ΔDP). |
| reflexive bladder volume | within 3 months before injection; within 2 months after injection | — |
| complications | within 2 months after injection | — |
| presence of urinary incontinence | within 3 months before injection; within 2 months after injection | — |
| maximum bladder volume | within 3 months before injection; within 2 months after injection | — |
Other
| Measure | Time frame | Description |
|---|---|---|
| lesion level | at the time of spinal cord injury | — |
| method of bladder evacuation | within 2 months after injection | evacuation by intermittent catheterization, reflex voiding, suprapubic catheter , electric stimulation |
| lesion severity | at the time of spinal cord injury | — |
Countries
Switzerland
Outcome results
None listed