Intrathecal Atropine to Prevent Postoperative Nausea and Vomiting

Intravenous Dexamethasone Combined With Intrathecal Atropine to Prevent Morphine-related Nausea and Vomiting After Cesarean Delivery: A Randomized Double-blinded Study

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03387956

Enrollment

120

Registered

2018-01-02

Start date

2017-03-20

Completion date

2017-08-10

Last updated

2018-06-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Nausea

Keywords

Postoperative Nuasea

Brief summary

optimal postoperative pain control with intrathecal morphine, with proper prevention of postoperative nausea and vomiting. Dexamethasone, and or atropine could offer some protection against nausea and vomiting.

Detailed description

One of the gold standards for analgesia following cesarean delivery is intrathecal morphine, which is not devoid of complications namely postoperative nausea and vomiting. We evaluated the antiemetic effect of intravenous dexamethasone combined with intrathecal atropine after cesarean delivery under spinal bupivacaine plus morphine anesthesia.

Interventions

DRUGIntrathecal atropine

100ug intrathecal atropine will be injected with spinal anesthesia

DRUGdexamethasone

intravenous 8 mg dexamethasone (2ml).

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

FEMALE

Age

20 Years to 40 Years

Healthy volunteers

Inclusion criteria

* females * 18-40 years of age * elective cesarean delivery under bupivacaine spinal anesthesia

Exclusion criteria

* renal disease * preeclampsia * liver disease * cardiac disease * Coagulopathy * chronic cough * nausea * vomiting * patient refusal

Design outcomes

Primary

Measure	Time frame	Description
postoperative nausea	24 hours	Monitoring scale of nausea and vomiting

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026