Healthy Subject
Conditions
Brief summary
Although the primary motor cortex is considered has the common final pathway of motor commands, it is influenced by several structures as, for example, the premotor cortex and the posterior parietal cortex which are involved in motor planning and programming and which integrates movement-induced sensory impute (parieto-frontal circuits). Several studies have shown that there are some direct functional connections between the premotor cortex and the posterior parietal cortex and from these two regions to the primary motor cortex. The posterior parietal cortex can then be considered as a sensorimotor interface whose function in planification and motor control of upper limb is well demonstrated. The hypothesis is that the posterior parietal cortex could participate to the modulation of motor cortex excitability by proprioceptive sensory inputs namely long latency afferent inhibition and afferent induced facilitation.
Interventions
DEVICETranscranial Magnetic Stimulation (TMS)
Transitory inactivation of the posterior parietal cortex and measure of sensorimotor integration.
DEVICEElectrical Muscle Activity (EMG)
Electrodes for the collection of EMG activity will be glued on the skin next to the first interosseus dorsalis muscle, the Abductor digiti minimi, the Extensor carpi radialis and the Abductor pollicis brevis. EMG signals will be stored on computer for off-line analysis using Signal © software (Cambridge Electronic Design, Cambridge, UK)
Sponsors
University Hospital, Lille
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Right handed * No neurological troubles * Informed consent signed * Affiliated to a social security
Exclusion criteria
* Psychiatric antecedent * Neurological disease * Contra-indication to TMS * Under psychiatric treatment * Pregnancy * Contra-indication to MRI
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Afferent induced facilitation | Baseline | Motor cortex facilitation following median nerve stimulation at interstimulus intervals of 70ms |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Interaction between long latency afferent inhibition and long latency intracortical inhibition (LICI) | Baseline | Effect of median nerve stimulation on LICI at 100ms interval |
Countries
France
Contacts
PRINCIPAL_INVESTIGATORPhilippe Derambure, MD, PhD
University Hospital, Lille
Outcome results
None listed