Headache Disorders
Conditions
Brief summary
Studying Carbon monoxide effects on brain vessels in healthy volunteers with magnetic resonance imaging.
Detailed description
In this study we will systematically investigate the headache-releasing properties of carbon monoxide as well as measure the effect of carbon monoxide on mean blood flow rate in the brain's large vessel with magnetic resonance imaging. These studies are important for understanding and further investigating the carbon monoxide's headache-releasing effect in healthy subjects.
Interventions
OTHERCarbon monoxide
Carbon monoxide inhalation
Sponsors
Danish Headache Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy volunteers * Aged 18-50 * 50-100 kg
Exclusion criteria
* Tension type headache more than 5 dage /month * Other primary headaches * Daily medication except contraceptives * Drug taken within 4 times the halflife for the specific drug except contraceptives * Pregnant or lactating women * Exposure to radiation within the last year * Headache within the last 24 hours before start of trial * Hypertension * Hypotension * Respiratory or cardiac disease * Smoking * Primary relatives with current or previous migraine
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in brain blood vessels diameters after a short CO inhalation | 30 minutes | To investigate changes in the circumference of intra- and extracerebral blood vessels after inhalation of carbon monoxide using magnetic resonance angiography (MRA). |
Countries
Denmark
Outcome results
None listed