Nutrition Status, BMD, and SSRIs

Nutrition Status, Bone Mass Density, and Selective Serotonin Reuptake Inhibitors

Status

Terminated

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03383861

Enrollment

13027

Registered

2017-12-26

Start date

2005-01-31

Completion date

2014-12-31

Last updated

2024-01-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

BMD

Brief summary

The association between selective serotonin reuptake inhibitor (SSRI) use and bone mass density (BMD) has been debated. Some have suggested features of depression, which SSRIs are prescribed to treat, may be a cause of decreased BMD, such as poor overall food intake at the time of SSRI use. Our study seeks to determine whether SSRI use in adults is associated with lower than average BMD, and if there is an association between low micronutrient intake, SSRI use, and a low BMD.

Interventions

DIAGNOSTIC_TESTDual-Energy X-ray Absorptiometry (DXA)

BMD t-score derived from DXA scan

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Included adult NHANES participants are those who participated in the Dual-Energy X-ray Absorptiometry (DXA) femur-neck BMD test and responded in full to the demographic, pharmaceutical, and dietary surveys.

Exclusion criteria

* Pregnancy, incomplete survey responses, incomplete DXA results

Design outcomes

Primary

Measure	Time frame
BMD t-score	NHANES DXA measurement taken 2005-2014

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026