Impact of Non Digestible Carbohydrate on Production of Phenolic Acids From Strawberry Juice

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03383809

Enrollment

Registered

2017-12-26

Start date

2017-04-28

Completion date

2019-07-06

Last updated

2019-07-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

Self-reported healthy adults

Brief summary

This is an acute human bioavailability study in self-reported healthy participants aged 20-70 years old. We hypothesize that combination of dietary polyphenolics and non-digestible carbohydrates (NDC) will increase the production of phenolic acids by bacteria in the human colon and these will be detected in urine. Participants will attend for three arms in a randomised order: Strawberry juice (a high polyphenol food), Inulin (NDC) or Mixture of strawberry juice and inulin.

Detailed description

Polyphenol rich plant foods have been associated with several health benefits but their bioavailability is generally low. The majority of plant polyphenols are poorly absorbed in the small intestine and enter the colon where the colonic microbiota metabolise them to release a range of phenolic acids, which are now thought to be the main bioactive components related to the reduction in disease risk. Very little is known about the impact of other constituents of the diet on the metabolism and bacterial catabolism of these polyphenols. The colonic microbiota are key agents in the release of the bioactive molecules from polyphenols but also ferment non-digestible carbohydrates (NDC) such as dietary fibre to short chain fatty acids. It is likely that there are key interactions in the colonic bacteria metabolism of fibre and phenolics. We hypothesize that combination of polyphenolics and non-digestible carbohydrates (NDC) will increase the urinary output of bioactive phenolic acids. This study will enable a better understanding of how to deliver combinations of ingredients and nutrients to achieve maximum nutritional value and health benefits.

Interventions

DIETARY_SUPPLEMENTInulin

Source of non digestible carbohydrate

DIETARY_SUPPLEMENTStrawberry juice with Inulin

Mixture of polyphenols and non digestible carbohydrates

DIETARY_SUPPLEMENTStrawberry Juice

Source of Polyphenols

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

NONE

Intervention model description

Acute human bioavailability studies with a cross-over design will be given to subjects in the form of a drink in one of three combinations 1. Strawberry juice alone 2. Inulin alone 3. Mixture of strawberry juice and inulin

Eligibility

Sex/Gender

ALL

Age

20 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

Self-reported healthy adults

Exclusion criteria

Antibiotic use within the last 3 months, identified gastro-intestinal diseases, on prescribed medication other than the contraceptive pill, individuals who are pregnant or breastfeeding. Individuals who have been diagnosed as anaemic, as well as those who are allergic to any food, or paracetamol.

Design outcomes

Primary

Measure	Time frame	Description
Phenolic acids bioavailability	0-24 hrs	Urine excretion of phenolic acids

Secondary

Measure	Time frame	Description
Urolithin bioavailability	0-24 hrs	Urine excretion of urolithins
Glycaemic and appetite hormones measurements by ELISA	0-8 hrs	Plasma glucose, insulin and appetite hormone levels
Mouth to caecum transit time	0-8 hrs	Breath hydrogen level measurements by Hydrogen monitor
Gastric emptying time	0-6 hrs	Plasma paracetamol levels by acetaminophen assay kits

Countries

United Kingdom

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026