Metabolomic Response to Meal Ingestion

Factors to Determine the Responses to Meal Ingestion: Circulating Metabolites

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03383250

Enrollment

Registered

2017-12-26

Start date

2014-11-15

Completion date

2017-10-15

Last updated

2018-01-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

meal ingestion, postprandial sensations, circulating metabolites

Brief summary

The investigators have recently shown that postprandial sensations correlate with changes in circulating metabolites after a meal ingestion; however this phenomenon was demonstrated with a meal load up to the level of tolerance which involved an unpleasant fullness sensation. The aim of the present study is to determine changes in circulating metabolites of a satiating pleasurable meal. Healthy men (n = 32) will be evaluated after a 5 h fast. Perception measurements and blood samples will be taken before and 20 minutes after ingestion of a palatable probe meal (juice and warm ham and cheese sandwich, total 300 ml, 440 kcal). NMR spectroscopy will be performed to determine plasmatic Low Molecular Weight Metabolites (LMWM) and to characterize lipoprotein profiles (number of particles, lipid content and size of the main three lipoprotein classes (VLDL, LDL and HDL). Homeostatic (satiety, fullness) and hedonic sensations (digestive well-being, mood) will be measured by 10 cm analogical scales.

Interventions

DIETARY_SUPPLEMENTNormal meal

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

OTHER

Masking

NONE

Eligibility

Sex/Gender

MALE

Age

18 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

* non obese

Exclusion criteria

* history of gastrointestinal symptoms * prior obesity * use of medications * history of anosmia and ageusia * current dieting * alcohol abuse * psychological disorders * eating disorders

Design outcomes

Primary

Measure	Time frame
Metabolomic response in serum	30 min

Secondary

Measure	Time frame	Description
Change in digestive well-being measured after the test meal	1 day	Change in average well-being measured by 10 score scales at the end of the test meal.
Change in satiety measured after the test meal	1 day	Change in average satiety measured by 10 score scales at the end of the test meal
Change in fullness sensation measured after the test meal	1 day	Change in average fullness measured by 10 score scales at the end of the test meal
Change in abdominal discomfort/pain sensation measured after the test meal	1 day	Change in average abdominal discomfort/pain measured by 10 score scales at the end of the test meal
Change in mood measured after the test meal	1 day	Change in average mood measured by 10 score scales at the end of the test meal.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026