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Vellus Hair Loss as a Marker for Peri-ocular Malignancy

Vellus Hair Loss as a Marker for Peri-ocular Malignancy

Status
Withdrawn
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT03382704
Enrollment
0
Registered
2017-12-26
Start date
2020-03-01
Completion date
2020-12-01
Last updated
2026-01-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Skin Cancer Face

Keywords

Peri-ocular

Brief summary

Skin cancers around the eye are common, but so are other lid lumps. It is useful to be able to tell which lumps are likely to be cancer. This study looks at whether the loss of fine hairs (vellus hairs) on the skin are a good indicator of whether a lump is a skin cancer or not. The investigators are recruiting patients who have lid lumps who haven't had a biopsy before, who would be having a biopsy as part of their treatment, and seeing whether those who have loss of the fine skin hairs are the same as those who have skin cancer confirmed on their biopsy. The study doesn't involve any extra examinations or treatments for participants. The investigators look at the patients before the biopsy as part of their usual care, and take a note of whether or not they have lost the fine hairs at this stage. The main benefit of participating is that the medical community has better evidence about which lid lumps are likely to represent skin cancer, helping future diagnosis. There are no additional risks to participating. The risks of biopsy are unchanged whether patients participate in the study or not. The study is run from the Princess Alexandra Eye Pavilion in Edinburgh. The investigators aim to start the study in Spring 2020, and will most likely recruit for 6 months depending on the number of participants recruited. There is no additional funding from any source at present - the work will be undertaken by doctors in their research time.

Interventions

DIAGNOSTIC_TESTExamination for presence or absence of vellus hairs

Pre-operative examination for presence or absence of vellus hairs

Sponsors

NHS Lothian
Lead SponsorOTHER_GOV
Moorfields Eye Hospital NHS Foundation Trust
CollaboratorOTHER

Study design

Observational model
CASE_ONLY
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* patients undergoing biopsy for peri-ocular lesion

Exclusion criteria

* Age under 18; previous biopsy or excision on the same lid

Design outcomes

Primary

MeasureTime frameDescription
Vellus hair presence/absenceDay 1Examination for the presence or absence of vellus hairs prior to biopsy
Biopsy resultOn receipt of biopsy result from pathology lab (~1 week)Biopsy result looking for malignancy

Countries

United Kingdom

Contacts

PRINCIPAL_INVESTIGATORRobert G Peden, MA; MBBS; FRCOphth

NHS Lothian

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026