Amyotrophic Lateral Sclerosis
Conditions
Keywords
Amyotrophic lateral sclerosis,, Resting energy expenditure, Predictive equation
Brief summary
Introduction: About 50-60% of Amyotrophic Lateral Sclerosis (ALS) is characterized by hypermetabolism, defined as 10% or more excess resting energy expenditure (REE) compared to theoretical values. Harris and Benedict's (HB) formula is the equation mainly used to predict REE, but others are also applied in current practice. The present study aimed to assess REE in ALS patients compared to control populations and to compare six formulas commonly used to predict REE. Nutritional assessments were performed in ALS patients and in two control populations without hypermetabolism: healthy elderly people (control 1) and patients with non-restrictive-eating disorders (control 2). Weight, height and body composition (by bioimpedance analysis) were assessed. EE was measured (mREE) by indirect calorimetry and calculated (cREE) using HB 1919 and 1984, World Schofield, De Lorenzo, Johnstone and Mifflin formulas. Mann-Whitney and Chi2 tests were used to compare the equations.
Interventions
OTHERAssesment of REE in ALS patients compared to control populations and to compare six formulas commonly used to predict REE.
Sponsors
University Hospital, Limoges
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* ALS patients * 18 years old or more * IC and nutritional assessment within 1.5 months * delay between diagnosis and IC \< 12 months
Exclusion criteria
\-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Measure of REE | indirect calorimetry (IC) and nutritional assessment within 1.5 months, and diagnosis and IC within 12 months | EE was measured (mREE) by indirect calorimetry and calculated (cREE) using Harris and Benedict's (HB) formula |
Countries
France
Outcome results
None listed