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Frailty and Post-operative Complications in Older Surgical Patients: The Implication of Frailty and Preoperative Risk Assessment

Frailty and Post-operative Complications in Older Surgical Patients: The Implication of Frailty and Preoperative Risk Assessment - A Retrospective Analysis

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT03382054
Enrollment
25000
Registered
2017-12-22
Start date
2016-06-01
Completion date
2022-12-31
Last updated
2023-06-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Frailty, Older Patients, Surgery

Brief summary

Frailty is prevalent in older adults and may be a better predictor of post-operative morbidity and mortality than chronological age. Preoperative risk factors and physiological reserves were assessed on patients more than 70 years old who are scheduled for surgery under general or regional anesthesia. The aim of this retrospective analysis was to examine the impact of relevant geriatric assessments on adverse outcomes in older surgical patients.

Detailed description

The goal of this study is to analyze the effect of frailty status on postoperative outcomes. These include postoperative complications (only ICD-10 coded diagnoses), length of hospitalization (ward/ICU), disposition, and survival. The project will also attempt to find synergism between a positive frailty status and common medical conditions (e.g. diabetes, congestive heart failure, coronary artery disease, dementia, and kidney disease), as well as anesthesiological and surgical processes (e.g. duration and type of anesthesia, surgical risk, and surgical discipline). Different assessment tools will be analyzed regarding their predictive power and clinical practicability. This should help improve preoperative risk assessment and allow for the multidimensional (physical, cognitive, social) identification of relevant frailty characteristics in the perioperative setting. All outcome parameters, including admission and discharge periods, will be collected using coded information from our hospital database. There will be no follow-up measurements after hospital discharge.

Interventions

None listed

Sponsors

Charite University, Berlin, Germany
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
70 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Male and female patients with age 70 years and above scheduled for surgery in the Department of Anesthesiology and Intensive Care Medicine (CCM, CVK), Charité - Universitätsmedizin Berlin

Design outcomes

Primary

MeasureTime frameDescription
Postoperative complications06/2016-12/2022ICD-10 coded diagnoses for the hospitalization

Secondary

MeasureTime frameDescription
Duration of Intensive Care Unit Stay06/2016-12/2022
Procedures06/2016-12/2022The procedures are measured regarding the following practices: anesthesiological, surgical, physiotherapeutic, social, cognitive, therapeutic, behavioral
Morbidity06/2016-12/2022
Ventilation06/2016-12/2022Ventilation is measured in hours.
Requirements for intensive care unit06/2016-12/2022
Intensive care unit scores06/2016-12/2022
Disease severity06/2016-12/2022
Duration of Hospital stay06/2016-12/2022
Mortality06/2016-12/2022Mortality is measured in hospital.
Medical costs06/2016-12/2022Costs incurred during hospitalization
Physiotherapy06/2016-12/2022Physiotherapy is measured by Physiotherapists support.
Nutritional therapy 106/2016-12/2022Nutritional consultations
Nutritional therapy 206/2016-12/2022Feeding
Post - intensive care syndrome06/2016-12/2022Post - Intensive care syndrome is measured by a cluster of symptoms that are unique to the Intensive care unit environment.
Postoperative Delirium06/2016-12/2022Delirium is measured with validated delirium scores.

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026