Task-dependent Operation of a Mechanism Intracortical Inhibition in Dystonia

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03381456

Acronym

LICIdystonie

Enrollment

Registered

2017-12-22

Start date

2015-04-30

Completion date

2017-04-30

Last updated

2017-12-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dystonia, Primary

Brief summary

Cortical excitability depends on inhibitory mechanisms efficiency among which long latency intracortical inhibition (LICI) can be studied by paired pulses transcranial magnetic stimulation (TMS). Some recent evidences suggest that LICI may be one of the mechanisms by which the motor comment is adapted to the ongoing motor task with LICI strength being dependent on task complexity. In writer cramp and musician cramp, two forms of dystonia, the cortical excitability is not correctly modulated in some complex gestures. the hypothesis is that this task dependent perturbation of excitability in writer cramp could be due to a lack of LICI efficiency.

Interventions

OTHERLICI

Paired pulse TMS to measure LICI and late cortical disinhibition

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Intervention model description

10 patient with dystonia and 10 healthy subject paired by sex and age.

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

* Patient with hand dystonia : writers cramp * Subject affiliated to social security regimen. For healthy volunteers : * Healthy volunteer without neurological disorders based on sensorimotor examination. * Subject affiliated to social security regimen.

Exclusion criteria

: * Subject unable to receive informed consent (dementia). * Contraindication to Transcranial Magnetic Stimulation(TMS) (epilepsia, intracranial metalic foreign object, hearing device, cochlear implant). * Patient using a psychotrope treatment. * Patient under guardianship or curatorship. * Pregnant or nursing women. * Patient with a cardiac stimulator. For healthy volunteers only : • Abnormal neurological evaluation based on sensorimotor examination or neurological history ( epilepsy, stroke ; brain or spinal cord surgery ; history of neurological disease affective sensitive and motor control)

Design outcomes

Primary

Measure	Time frame	Description
long-interval intracortical inhibition (LICI) level	Baseline	Amount of inhibition at interstimulus intervals of between 50 to 300ms

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026