Competing Risk of Death and ESRD in Incident CKD Patients

Competing Risk of Death and End-stage Renal Disease in Incident Chronic Kidney Disease (Stages 3 to 5): the EPIRAN Community-based Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03379571

Acronym

EPIRAN

Enrollment

631

Registered

2017-12-20

Start date

2004-01-01

Completion date

2009-12-31

Last updated

2017-12-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Kidney Diseases

Keywords

Chronic kidney disease, Competing-risk analysis, Epidemiological study, Incidence, Outcomes, Risk factors

Brief summary

Although chronic kidney disease (CKD) affects a growing number of people, epidemiologic data on incident CKD in the general population are scarce. Screening strategies to increase early CKD detection have been developed. Methods: From a community-based sample of 4,409 individuals residing in a well-defined geographical area, investigators determined the number of patients having a first serum creatinine value ≥1.7 mg/dL and present for at least 3 months that allowed us to calculate an annual incidence rate of CKD (stages 3 to 5). CKD (stages 3 to 5) was defined by estimated glomerular filtration rate (eGFR) \<60 mL/min/1.73 m2. Investigators also described the primary care, outcomes and risk factors associated with outcomes using competing risks analyses for these CKD patients.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Inclusion criteria

* \>= 18 years * first serum creatinine value ≥1.7 mg/dL reached after January 1st, 2004 * and present for at least 3 months * residing in the given geographical area (the Urban Community of Greater Nancy (UCGN))

Exclusion criteria

* \<18 years * prevalent CKD patient : CKD diagnosis before January 1st, 2004 * patients on dialysis or renal transplanted * refusal of participation

Design outcomes

Primary

Measure	Time frame	Description
annual incidence rate of CKD	inclusion	number of patients residing in a well-defined geographical area having a first serum creatinine value ≥1.7 mg/dL after January 1st, 2004 and still present for at least 3 months

Secondary

Measure	Time frame	Description
dialysis initiation	through study completion, 6 year after study start	number of dialysis initiation.
death	through study completion, 6 year after study start	number of death
management of CKD patients	through study completion, 6 year after study start	%patients referred to a nephrologist, decline of the renal function

Outcome results