Pain Relief and Functional Outcome After Partial Denervation of the Wrist

A Prospective Study on Pain Relief and Functional Outcome After Partial Denervation of the Wrist

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03378362

Enrollment

Registered

2017-12-19

Start date

2017-12-31

Completion date

2021-08-31

Last updated

2022-03-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Wrist Arthritis

Brief summary

Prospective study on the effect of partial wrist denervation (ie combined anterior and posterior interosseous neurectomy) on pain relief on functional outcome in patient with wrist osteoarthritis. The impact of psychological factors on postoperative outcome will be studied.

Interventions

PROCEDUREPartial denervation of the wrist joint

Partial denervation of the wrist (posterior and anterior interosseous neurectomy) through a single dorsal approach.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

1. Chronic wrist pain (≥6 months) due to posttraumatic arthritis after distal radius fracture or SLAC/SNAC arthritis or arthritis due to Mb Preiser/Mb Kienböck where surgical unloading of the bone isn't possible. 2. Pain is refractory to nonsurgical management such as bracing, corticosteroid injection, oral analgesics, NSAIDs, physiotherapy.

Exclusion criteria

1. Rheumatoid or other inflammatory arthritis. 2. Previous wrist surgery with simultaneous PIN/AIN neurectomy. 3. Simultaneous arthritis or symptomatic instability of the distal radio ulnar (DRU) joint on the ipsilateral side. 4. Inability to co-operate with the follow-up protocol (language difficulties, severe psychiatric disorder, cognitive impairment, drug addiction). 5. Patient's wish for a definite procedure.

Design outcomes

Primary

Measure	Time frame	Description
Change in Disability of the Arm, Shoulder and Hand score (DASH)	peroperatively, 3, 6 and 12 months postoperatively	questionnaire

Secondary

Measure	Time frame	Description
Change in Patient Related Wrist Evaluation (PRWE)	peroperatively, 3, 6 and 12 months postoperatively	questionnaire
Change in EQ5D	peroperatively, 3, 6 and 12 months postoperatively	questionnaire
Change in Hospital Anxiety and Depression Scale (HADS)	peroperatively, 3, 6 and 12 months postoperatively	questionnaire. Determines the levels of anxiety and depression. 14 item scale that generates ordinal data. Seven items relate to anxiety and seven to depression. Each item is scored from 0-3, which means that a person can score between 0-21 for either depression or anxiety. A score of 11 or above on either scale in considered to repressent depression or anxiety.
Change in range of motion, grip strength	peroperatively, 3, 6 and 12 months postoperatively	objective physical function
Change in Sence Of Coherence -13 (SOC13)	peroperatively, 3, 6 and 12 months postoperatively	Questionnaire

Countries

Sweden

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026